ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS [PDF]
, 2010 Angela Alexander +13 more
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m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An +7 more
wiley +1 more source
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice [PDF]
, 2010 Denghong Zhang +16 more
openalex +1 more source
A Drosophila model of prion disease and its metabolic changes in the brain
Animal Models and Experimental Medicine, EarlyView.We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang +14 more
wiley +1 more source
A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions [PDF]
, 2010 Marta M. Lipinski +11 more
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Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang +5 more
wiley +1 more source
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
Cell Reports, 2017 Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis.
Gerta Hoxhaj +7 more
doaj
Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma [PDF]
, 2010 Diego F. Calvisi +14 more
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Hepatic gluconeogenesis and regulatory mechanisms in lactating ruminants: A literature review
Animal Research and One Health, EarlyView.phosphoenolpyruvate carboxy kinase, FBP1, and glucose‐6‐phosphatase are key rate‐limiting enzymes that determine the efficiency of gluconeogenesis. The main substrate for gluconeogenesis in the liver of ruminants is propionate, which provides more than 60% of the carbon source for gluconeogenesis.
Guoyan Wang +5 more
wiley +1 more source