Results 221 to 230 of about 108,192 (330)

SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport. [PDF]

J Immunol
Tao AY, Hu K, Noyer L, Zhong L, Li W, Wang L, Feske S.   +6 more
europepmc   +1 more source

Supplementary Figure 10 from Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways

, 2023
Hiu‐Fung Yuen, Ka‐Kui Chan, Claire Grills, James T. Murray, Angela Platt‐Higgins, Osama Sharaf Eldin, Kenneth J. O’Byrne, Pasi A. Jänne, Dean A. Fennell, Patrick G. Johnston, Philip S. Rudland, Mohamed El‐Tanani   +11 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Rôle de la voie mTORC1/S6K1 dans la régulation de la signalisation de l'insuline dans les adipocytes

, 2007
Alain Veilleux
openalex   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

MCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis. [PDF]

Nat Commun
Gui W, Paral P, Dhamija B, Hagag E, Dusa M, Humajova J, Francova PV, Kucka J, Pankrac J, Schütz C, Armenis V, Ferrucci F, Schubert M, Guan K, Baenke F, Stange DE, Lehmann LH, Weckwerth W, Mirtschink P, Traikov S, Giuseppe B, Miracco C, Bornhäuser M, Minucci S, Sefc L, Macurek L, Elgendy M.   +26 more
europepmc   +1 more source

TABLE 2 from Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with <i>mTOR/AKT/PI3K</i> Pathway Alterations and Advanced Solid Malignancies

Vivek Subbiah, Niamh Coleman, Sarina A. Piha‐Paul, Apostolia M. Tsimberidou, Filip Jankú, Jordi Rodón, Shubham Pant, Ecaterina E. Dumbrava, Siqing Fu, David S. Hong, Shizhen Zhang, Ming Sun, Yunfang Jiang, Jason Roszik, Juhee Song, Ying Yuan, Funda Meric‐Bernstam, Aung Naing   +17 more
openalex   +1 more source

Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 343-357, March 2026.
Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman, Oscar Horwath, Eva Pontén, Sudarshan Dayanidhi, Ferdinand von Walden   +4 more
wiley   +1 more source

B Cell–Intrinsic mTORC1 Promotes Germinal Center–Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity [PDF]

, 2018
Ariel Raybuck, Sung Hoon Cho, Jingxin Li, Meredith C. Rogers, Keunwook Lee, Christopher L. Williams, Mark J. Shlomchik, James W. Thomas, Jin Chen, John V. Williams, Mark Boothby   +10 more
openalex   +1 more source

Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice

Immunology, Volume 177, Issue 3, Page 481-500, March 2026.
The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han, Xi Xu, Yan Zhao, Yao Xiao, Fei Huang, Jing Zhou, Hai Huang, Guiqian Wang   +7 more
wiley   +1 more source