Results 271 to 280 of about 75,068 (344)

Orchestrating Neural Development Through mRNA Translation Regulation. [PDF]

J Neurochem
Rodrigue B, Sajish M, Salmaso N, Aguilar-Valles A.   +3 more
europepmc   +1 more source

Faculty Opinions recommendation of mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

, 2011
Michael G. Roth
openalex   +2 more sources

Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Obesity promotes the progression of intervertebral disc degeneration (IVDD) through the mTORC1/FABP4 axis. Targeting FABP4 effectively ameliorates nucleus pulposus dysfunction and angiogenesis in obesity‐related IVDD. ABSTRACT Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic ...
Lin Han, Fudong Li, Huiqiao Wu, Weiheng Wang, Peiwen Chen, Weicheng Xia, Yang Liu, Kaiqiang Sun, Wenbo Lin   +8 more
wiley   +1 more source

Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation. [PDF]

Cancer Res
Elkholi IE, Robert A, Malouf C, Wu JL, Kuasne H, Drapela S, Macleod G, Hébert S, Pacis A, Calderon V, Kleinman CL, Gomes AP, Alvarez JV, Aguirre-Ghiso JA, Park M, Angers S, Côté JF.   +16 more
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Transcriptome Remodeling and Adaptive Preservation of Muscle Protein Content in Hibernating Black Bears. [PDF]

Ecol Evol
Fedorov VB, Garreau A, Tøien Ø, Barnes BM, Goropashnaya AV.   +4 more
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

β-catenin safeguards cell survival via a transcription-independent mechanism during the induction of primitive streak from hESCs. [PDF]

Cell Death Discov
Zhang P, Li XX, Bai HJ, Zhao Y, Rao S, Liang H, Luo XL, Yang HT.   +7 more
europepmc   +1 more source

Cilia downsize mTORC1 [PDF]

Nature Reviews Molecular Cell Biology, 2010
openaire   +2 more sources

Research Advances of the Autophagy‐Regulated Radiosensitivity

Cell Proliferation, EarlyView.
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu, Yanlan Xiao, Chuhao Dai, Keyu Chen, Xinyi Xu, Jianming Cai, Xuguang Hu, Jiaming Guo   +7 more
wiley   +1 more source