Results 21 to 30 of about 108,192 (330)
Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]
, 2018 The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan +6 more
core +2 more sources
mTORC2 signaling drives the development and progression of pancreatic cancer [PDF]
, 2016 mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex.
Bardeesy, Nabeel +17 more
core +1 more source
Increased mTORC1 Signaling UPRegulates Stress [PDF]
Molecular Cell, 2008 In this issue of Molecular Cell, Ozcan et al. (2008) show that the loss of the tuberous sclerosis tumor suppressor complex induces endoplasmic reticulum stress, leading to attenuation of insulin receptor signaling activity via the unfolded protein response.
Reiling, Jan H., Sabatini, David M.
openaire +2 more sources
p16: cycling off the beaten path
Molecular & Cellular Oncology, 2019 p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-
Raquel Buj, Katherine M. Aird
doaj +1 more source
PIKFYVE-dependent regulation of MTORC1 and TFEB
Autophagy Reports, 2022 TFEB (transcription factor EB) is essential for the upregulation of gene expression required for macroautophagy/autophagy and lysosomal function. Under nutrient-rich conditions, TFEB is inactivated by MTOR (mechanistic target of rapamycin kinase) complex
Junya Hasegawa +2 more
doaj +1 more source
p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
doaj +1 more source
Rag GTPases are cardioprotective by regulating lysosomal function. [PDF]
, 2014 The Rag family proteins are Ras-like small GTPases that have a critical role in amino-acid-stimulated mTORC1 activation by recruiting mTORC1 to lysosome.
Guan, Kun-Liang +8 more
core +2 more sources
mTORC1 Regulates Glutamine Metabolism [PDF]
Cancer Discovery, 2013 Abstract mTORC1 stimulates glutamine metabolism by inducing glutamate dehydrogenase (GDH).
openaire +2 more sources
SNAT7 regulates mTORC1 via macropinocytosis
Proceedings of the National Academy of Sciences, 2022 Significance The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1.
Delong Meng +13 more
openaire +2 more sources
A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma
Autophagy Reports, 2022 The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 ...
Sujoy Bhattacharya +2 more
doaj +1 more source