Results 21 to 30 of about 75,068 (344)

Cellular Uptake, Metabolism and Sensing of Long-Chain Fatty Acids

Frontiers in Bioscience-Landmark, 2023
Fatty acids (FAs) are critical nutrients that regulate an organism’s health and development in mammal. Long-chain fatty acids (LCFAs) can be divided into saturated and unsaturated fatty acids, depending on whether the carbon chain contains at least 1 ...
Qiburi He, Yuhao Chen, Zhigang Wang, Hu He, Peng Yu   +4 more
doaj   +1 more source

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

Science, 2022
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling (LYCHOS, previously annotated as G ...
Hijai R. Shin, Y. R. Citron, Lei Wang, Laura Tribouillard, Claire Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, R. Perera, E. Park, D. Covey, Mathieu Laplante, A. Evers, R. Zoncu   +19 more
semanticscholar   +1 more source

COVID 19 in a family with rare genetic disease of the nervous system

Неврология, нейропсихиатрия, психосоматика, 2022
We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and ...
M. Yu. Martynov, V. A. Kutashov, O. V. Ulyanova   +2 more
doaj   +1 more source

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Nature Communications, 2022
Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis.
Cyril Statzer, Jin Meng, Richard Venz, Monet S Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole M. Haynes, William B. Mair, A. Longchamp, M. Filipović, T. Blackwell, C. Ewald   +15 more
semanticscholar   +1 more source

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway

Clinical and Experimental Hypertension, 2023
Background In-stent restenosis hardly limits the therapeutic effect of the percutaneous vascular intervention. Although the restenosis is significantly ameliorated after the application of new drug-eluting stents, the incidence of restenosis remains at a
Ke Peng, Mingliang Wang, Jun Wang, Qiang Wang, De Li, Xiongshan Sun, Yongjian Yang, Dachun Yang   +7 more
doaj   +1 more source

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Cell Stress, 2021
Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity ...
Constantinos Demetriades, Julian Nüchel, Markus Plomann   +2 more
doaj   +1 more source

Micro(RNA) Managing by mTORC1 [PDF]

Molecular Cell, 2015
In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.
Jewell, Jenna L, Flores, Fabian, Guan, Kun-Liang   +2 more
openaire   +5 more sources

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Nature Communications, 2020
mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1KO) reduces muscle mass.
G. D’Hulst, Ines Soro-Arnaiz, Evi Masschelein, K. Veys, Gillian Fitzgerald, B. Smeuninx, Sunghoon Kim, L. Deldicque, B. Blaauw, P. Carmeliet, L. Breen, P. Koivunen, Shi-min Zhao, Katrien de Bock   +13 more
semanticscholar   +1 more source

Multistep regulation of TFEB by MTORC1 [PDF]

Autophagy, 2017
The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization. However, TFEBS211A localizes diffusely in both cytoplasm and nucleus and, as we show, retains regulation by MTORC1.
Vega-Rubín-de-Celis, Silvia, Peña-Llopis, Samuel, Konda, Meghan, Brugarolas, James   +3 more
openaire   +4 more sources

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

Nature Cell Biology, 2022
Amino acid availability controls mTORC1 activity via a heterodimeric Rag GTPase complex that functions as a scaffold at the lysosomal surface, bringing together mTORC1 with its activators and effectors.
Peter Gollwitzer, Nina Grützmacher, S. Wilhelm, D. Kümmel, C. Demetriades   +4 more
semanticscholar   +1 more source