Results 31 to 40 of about 102,812 (293)
PIKFYVE-dependent regulation of MTORC1 and TFEB
Autophagy Reports, 2022 TFEB (transcription factor EB) is essential for the upregulation of gene expression required for macroautophagy/autophagy and lysosomal function. Under nutrient-rich conditions, TFEB is inactivated by MTOR (mechanistic target of rapamycin kinase) complex
Junya Hasegawa +2 more
doaj +1 more source
p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
doaj +1 more source
Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]
, 2014 The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 (mTOR complex 1) activation with the ...
Amy Patton +12 more
core +5 more sources
Suppressing mTORC1 on the lysosome [PDF]
The EMBO Journal, 2017 The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi‐subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets. While class I phosphoinositide
Camilla Raiborg +2 more
openaire +2 more sources
A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma
Autophagy Reports, 2022 The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3) and STAT3 ...
Sujoy Bhattacharya +2 more
doaj +1 more source
Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]
, 2014 Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora +68 more
core +6 more sources
Regulation of adiposity by mTORC1 [PDF]
Einstein (São Paulo), 2017 ABSTRACT Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etiology to develop new therapeutic strategies ...
Magdalon, Juliana +1 more
openaire +5 more sources
p16: cycling off the beaten path
Molecular & Cellular Oncology, 2019 p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-
Raquel Buj, Katherine M. Aird
doaj +1 more source
Autophagy Function and Regulation in Kidney Disease
Biomolecules, 2020 Autophagy is a dynamic process by which intracellular damaged macromolecules and organelles are degraded and recycled for the synthesis of new cellular components.
Gur P. Kaushal +3 more
doaj +1 more source
RETREG3/FAM134C phosphorylation by CSNK2 regulates reticulophagy during starvation
Autophagy Reports, 2022 Starvation is the most potent physiological inducer of autophagy, the catabolic process which degrades unessential cytosolic components to sustain cellular homeostasis and survival.
Giorgia Di Lorenzo +4 more
doaj +1 more source