Results 31 to 40 of about 75,068 (344)
Nature Communications, 2021 Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential treatments for COVID-19. Here we profile metabolic changes conferred by SARS-CoV-2
P. Mullen +15 more
semanticscholar +1 more source
An expanded role for mTORC1 in autophagy [PDF]
Molecular & Cellular Oncology, 2015 Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1.
Douglas Grunwald +3 more
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p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
doaj +1 more source
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
Science, 2022 The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in response to nutrients, including the amino acid leucine. In cultured cells, mTORC1 senses leucine through the leucine-binding Sestrin proteins, but the physiological ...
Andrew L Cangelosi +13 more
semanticscholar +1 more source
Rapamycin inhibits mTORC1, but not completely [PDF]
Autophagy, 2009 Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
Thoreen, Carson C, Sabatini, David
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The role of mTOR in age-related diseases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The ageing population is becoming a significant socio-economic issue. To address the expanding health gap, it is important to deepen our understanding of the mechanisms underlying ageing in various organisms at the single-cell level. The discovery of the
Zofia Chrienova +2 more
doaj +1 more source
Regulation of mTORC1 by amino acids [PDF]
Trends in Cell Biology, 2014 The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the ...
Bar-Peled, Liron, Sabatini, David
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Spatiotemporal feedforward between PKM2 tetramers and mTORC1 prompts mTORC1 activation
Physical Biology, 2022 Abstract Most mammalian cells couple glucose availability to anabolic processes via the mTORC1 pathway. However, the mechanism by which fluctuations in glucose availability are rapidly translated into mTORC1 signals remains elusive. Here, we show that cells rapidly respond to changes in glucose availability through the spatial coupling ...
Yu Xia +3 more
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Journal of Inflammation Research, 2021 Qianxue Mou,1 Ke Yao,1 Meng Ye,1 Bowen Zhao,1 Yuanyuan Hu,1 Xiaotong Lou,1 Huixia Li,2 Hong Zhang,1 Yin Zhao1 1Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s ...
Mou Q +8 more
doaj
Cell Cycle, 2012 A balance must be struck between cell growth and stress responses to ensure that cells proliferate without accumulating damaged DNA. This balance means that optimal cell proliferation requires the integration of pro-growth and stress-response pathways. mTOR (mechanistic target of rapamycin) is a pleiotropic kinase found in complex 1 (mTORC1).The mTORC1
Paul Hasty +3 more
openaire +3 more sources