Results 171 to 180 of about 4,722 (199)

MTRR and MTHFR polymorphism: Link to Down syndrome?

American Journal of Medical Genetics, 2001
AbstractPolymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome. We examined the prevalence of these variant genotypes in mothers who had given birth to a child with Down syndrome (n = 48) and in ...
Valerie B, O'Leary, Anne, Parle-McDermott, Anne M, Molloy, Peadar N, Kirke, Zachary, Johnson, Mary, Conley, John M, Scott, James L, Mills   +7 more
openaire   +2 more sources

MTRR A66G polymorphism and breast cancer risk: a meta-analysis

Breast Cancer Research and Treatment, 2010
Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk. However, this relationship remains inconclusive. For better understanding the effect of MTRR A66G polymorphism on breast cancer risk, a meta-analysis was ...
Jia, Hu, Guo-Wu, Zhou, Ning, Wang, Ya-Jie, Wang   +3 more
openaire   +2 more sources

Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population

Gene, 2014
Folate pathway is expected to play an important role in spermatogenesis since it is involved in DNA synthesis, repair and methylation. The purpose of this study was to examine the association between male infertility and the MTHFR (C677T and A1298C) and MTRR (A66G) polymorphisms. A group of 300 males was recruited in this study from different Jordanian
Doaa S, Mfady, May F, Sadiq, Omar F, Khabour, Abdulfattah S, Fararjeh, Aymen, Abu-Awad, Yousef, Khader   +5 more
openaire   +2 more sources

Genetic polymorphism of GST, NAT2, and MTRR and susceptibility to childhood acute leukemia

Molecular Biology, 2008
It is known that presence of xenobiotic-metabolizing gene polymorphisms in some cases correlates with hereditary predisposition to the oncological diseases. In the present work the frequencies of xenobiotic-metabolizing gene polymorphisms in 332 children with the diagnosis acute lymphoblastic leukemia (ALL), 71 children with the diagnosis acute ...
O A, Gra, A S, Glotov, Zh m, Kozhekbaeva, O V, Makarova, T V, Nasedkina   +4 more
openaire   +2 more sources

Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms With Being Overweight/Obesity on the Risk of Type 2 Diabetes

International Journal of Environmental Research and Public Health, 2016
Although both methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms have been associated with type 2 diabetes (T2D), their interactions with being overweight/obesity on T2D risk remain unclear.
Guifan Sun, Shujun Fan, Xueyuan Zhi
exaly   +2 more sources

The role of MTHFR and MTRR gene polymorphisms in the development of cholelithiasis

Experimental and Clinical Gastroenterology
In recent years, statistical studies show that cholelithiasis is detected in every fifth woman and every tenth man. Сholelithiasis is a multifactorial process that is influenced by both environmental and genetic factors. Some evidence suggests that total plasma homocysteine correlates with the presence of gallstones, suggesting that ...
Yu. Yu. Fedorova, A. Kh. Nurgalieva, S. G. Petrova, R. R. Murzina, M. A. Dzhaubermezov, N. V. Ekomasova, E. K. Khusnutdinova, D. S. Prokofieva   +7 more
openaire   +1 more source

The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2015
Preeclampsia (PE) is a major cause of maternal and perinatal mortality and morbidity. The studies suggest that both polymorphisms and changes of expression in genes encoding enzymes involved in the methionine and homocysteine metabolism (MHM), such as methylenetetrahydrofolate, reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase
Agnieszka, Seremak-Mrozikiewicz, Anna, Bogacz, Joanna, Bartkowiak-Wieczorek, Hubert, Wolski, Boguslaw, Czerny, Malgorzata, Gorska-Paukszta, Krzysztof, Drews   +6 more
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Folate Deficiency and Gene Polymorphisms of MTHFR, MTR and MTRR Elevate the Hyperhomocysteinemia Risk

Clinical Laboratory, 2017
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). We aimed to investigate the joint effect of homocysteine metabolism gene polymorphisms, as well as the folate deficiency on the risk of HHcy in a Chinese hypertensive population.This study enrolled 480 hypertensive patients aged 28 - 75 from six hospitals in ...
Wen-Xing, Li, Fei, Cheng, A-Jie, Zhang, Shao-Xing, Dai, Gong-Hua, Li, Wen-Wen, Lv, Tao, Zhou, Qiang, Zhang, Hong, Zhang, Tao, Zhang, Fang, Liu, Dahai, Liu, Jing-Fei, Huang   +12 more
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An Inframe Trinucleotide Deletion in MTRR Exon 1 is Associated with the Risk of Spina Bifida

NeuroMolecular Medicine, 2017
Maternal genetic variants of enzymes in folate-homocysteine metabolic network are significantly correlative with the risk of spina bifida. To survey the genetic causality, the genotypes of three women having spina bifida fetuses from two unrelated Chinese families were screened in candidate alleles.
Jun, Zhang, Xiao-Lu, Dai, Gui-Cen, Liu, Juan, Wang, Xue-Yi, Ren, Mu-Hua, Jin, Nan-Nan, Mi, Shu-Qin, Wang   +7 more
openaire   +2 more sources

Associations of MTRR and TSER polymorphisms related to folate metabolism with susceptibility to metabolic syndrome

Genes & Genomics, 2019
Hyperhomocysteinemia is a potential risk factor for the development of metabolic syndrome (MetS). Among genes involved in homocysteine metabolism, polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are known to be associated with MetS incidence.
Young Ree, Kim, Seung-Ho, Hong
openaire   +2 more sources