Results 81 to 90 of about 4,722 (199)
The Journal of Physiology, Volume 603, Issue 19, Page 5751-5775, October 1, 2025.Abstract figure legend Uteroplacental insufficiency (growth restricted) or sham (Control) surgery was performed on embryonic day (E)18 in Wistar–Kyoto rats. Female F1 offspring were mated and restricted dams received daily metformin, insulin or vehicle from E13.
Dayna A. Zimmerman +11 more
wiley +1 more source
Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect [PDF]
, 2017 Background. Congenital heart defect (CHD) is one of the most common birth defects in the world. The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD ...
Qian-nan Guo +6 more
core +1 more source
Акушерство, гинекология и репродукцияAim: to assess associations between folate cycle gene polymorphism and neonatal birth weight in pregnant women with fetal growth retardation (FGR) and related functional effects in population of the Central Black Earth Region.Materials and Methods.
Yu. N. Reshetnikova +5 more
doaj +1 more source
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT Cobalamin (vitamin B12) is an essential cofactor for two human enzymes, methionine synthase and methylmalonyl‐CoA mutase. Inborn errors of cobalamin metabolism (IECMs) are inherited genetic defects resulting in improper transport, modification, or utilization of cobalamin and include inherited methylmalonic acidurias, a group of IECMs most ...
Almut Heinken +5 more
wiley +1 more source
Distribution of Methionine Synthase Reductase (MTRR) Gene A66G Polymorphism in Indian Population
Indian Journal of Clinical Biochemistry, 2019 Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity.
Upendra Yadav +2 more
openaire +3 more sources
Gynecological EndocrinologyGestational diabetes mellitus (GDM) is a common pregnancy complication with rising incidence and adverse maternal-fetal outcomes. Genetic polymorphisms in folate metabolism genes may influence GDM susceptibility through homocysteine pathway alterations ...
Wei Han +5 more
doaj +1 more source
Российский кардиологический журнал, 2020 Aim. To determine the heart failure (HF) risk in patients with hypertension (HTN) and high adherence to treatment, depending on the blood concentration of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and gene polymorphism.Material and methods.
N. A. Koziolova, A. I. Chernyavina
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Food Science &Nutrition, Volume 13, Issue 7, July 2025.Neurotoxicity of Hcy. (A figure that best represents the scope of the paper.) Homocysteine can reduce the tightness of endothelial cell connections, increase vascular permeability, and damage the blood–brain barrier. Homocysteine activates various glutamate receptors on the surfaces of neurons and glial cells, triggering excitotoxicity, promoting the ...
Bin Li, Yushun Kou, Lingna Zhang, Lin Yi
wiley +1 more source
BiologyIntroduction: Preeclampsia is a severe multifactorial complication of pregnancy. Studies found associations between folate metabolism genes’ polymorphisms and preeclampsia. However, investigations in this field are limited among Asian populations.
Lyazzat Kaldygulova +5 more
doaj +1 more source
Factors determining homocysteine levels in Russian patients with stable coronary heart disease
Кардиоваскулярная терапия и профилактика, 2010 Aim. To identify the factors determining homocysteine (HMC) levels in Russian patients with stable coronary heart disease (CHD). Material and methods. The study included 506 patients (388 men; mean age 59,4±12,2 years) with stable CHD.
O. O. Shakhmatova +9 more
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