Results 11 to 20 of about 191,997 (296)

Immunohistochemical Expression of HER2/neu, Ki-67 and MUC1 in Benign and Malignant Gall Bladder Lesions and its Association with Clinicopathological Parameters [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Gall Bladder Carcinoma (GBC) is a diagnostic and a therapeutic challenge. Although it is increasing, chronic cholecystitis remains the most worldwide gall bladder lesions, harbouring many epithelial changes that may end in carcinoma ...
Rania G Roshdy, Heba M Rashad, Enas Ibrahim   +2 more
doaj   +1 more source

Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland

Frontiers in Endocrinology, 2021
Follicular thyroid tissue originates from progenitors derived from a midline endodermal primordium. Current understanding infers that folliculogenesis in the embryonic thyroid designates the latest morphogenetic event taking place after the final ...
Ellen Johansson, Shawn Liang, Carmen Moccia, Therese Carlsson, Daniel Andersson, Henrik Fagman, Henrik Fagman, Henrik Fagman, Mikael Nilsson   +8 more
doaj   +1 more source

Mucin 16, the dimerization copycat of mucin 1?

The FASEB Journal, 2021
Mucin 1 (MUC1), a transmembrane mucin that serves a protective role by inhibiting extracellular pathogens from entering epithelial cells is also implicated in forming cancerous cells through dimer formation. Upon expression and localization in the membrane, MUC1 proteins form cysteine‐dependent homodimers through the juxtamembrane domain CQC motif. The
Robert Murphy, Nicole Butch, Edwin Li
openaire   +1 more source

Irradiation Alters the Expression of MUC1, CD44 and Hyaluronan in Oral Mucosal Epithelium

Biomedicines, 2022
Purpose: It is well established that cancer cells exploit aberrant synthesis of mucin 1 (MUC1) and hyaluronan (HA) synthesis along with HA’s physiological cell surface receptor CD44.
Bina Kashyap, Konsta Naumanen, Jopi Mikkonen, Hannah Dekker, Engelbert Schulten, Elisabeth Bloemena, Sanna Pasonen-Seppänen, Arja Kullaa   +7 more
doaj   +1 more source

Preliminary Development and Testing of C595 Radioimmunoconjugates for Targeting MUC1 Cancer Epitopes in Pancreatic Ductal Adenocarcinoma

Cells, 2022
Mucin 1 is a transmembrane glycoprotein which overexpresses cancer-specific epitopes (MUC1-CE) on pancreatic ductal adenocarcinoma (PDAC) cells. As PDAC is a low survival and highly aggressive malignancy, developing radioimmunoconjugates capable of ...
Ashleigh Hull, Yanrui Li, Dylan Bartholomeusz, William Hsieh, William Tieu, Tara L. Pukala, Alexander H. Staudacher, Eva Bezak   +7 more
doaj   +1 more source

⁸⁹Zr-Labeled AR20.5: A MUC1-Targeting ImmunoPET Probe

Molecules, 2020
High expression levels of the tumor-associated antigen MUC1 have been correlated with tumor aggressiveness, poor response to therapy, and poor survival in several tumor types, including breast, pancreatic, and epithelial ovarian cancer. Herein, we report
Kimberly Fung, Delphine Vivier, Outi Keinänen, Elaheh Khozeimeh Sarbisheh, Eric W. Price, Brian M. Zeglis   +5 more
doaj   +1 more source

Clinicopathological Factors Affecting Mucin 1, Mucin 2, and Mucin 5AC Staining in Patients who Underwent Resection for Colorectal Cancer

Journal of the College of Physicians and Surgeons Pakistan, 2023
To investigate the clinicopathological factors affecting mucins (MUC 1, MUC 2, and MUC 5AC) staining in patients who underwent resection for colorectal cancer.An observational study. Place and Duration of the Study: Department of General Surgery and Department of Pathology, Kafkas University Faculty of Medicine, Kars, Turkey, between January 2020 and ...
Turgut, Anuk, Hatice, Beseren, Yalcin, Polat, Ozkan, Ozden, Tolga, Kalayci   +4 more
openaire   +2 more sources

Mucin Level as a Potential Biomarker for Breast Cancer Diagnosis

MCBS (Molecular and Cellular Biomedical Sciences), 2022
Background: Breast cancer is the second leading cause of cancer death and a health problem worldwide. Secreted mucins are upregulated in ductal adenocarcinoma of the breast, however, the use of mucin as breast cancer biomarker has not been established ...
Tagwa Sayed Abdihalim, Alkhair Abd Almahmoud Idris   +1 more
doaj   +1 more source

Evaluation of a Novel Anti-Mucin 1 (MUC1) Antibody (PankoMab) as a Potential Diagnostic Tool in Human Ductal Breast Cancer; Comparison with Two Established Antibodies [PDF]

, 2009
Aim: PankoMab is a novel antibody that recognizes a tumor-specific epitope of Mucin 1 (MUC1). The aim of this study was the evaluation of PankoMab as a potential diagnostic tool and its comparison with two established antibodies against MUC1 in human ...
Dian, Darius, Friese, Klaus, Janni, Wolfgang, Jeschke, Udo, Karsten, Uwe, Kuhn, Christina, Mayr, Doris, Mylonas, Ioannis   +7 more
core   +1 more source

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon [PDF]

, 2015
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia.
Clara Belzer, Giovannucci, Guido J. Hooiveld, Jan Dekker, Lapré, McGarr, Michael Müller, Michiel Kleerebezem, Noortje Ijssennagger, Roelof van der Meer, Saskia W. C. van Mil, Sesink, Sheffner, van Klinken   +13 more
core   +2 more sources