Salivary mucins in host defense and disease prevention
Journal of Oral Microbiology, 2015 Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical ...
Erica Shapiro Frenkel, Katharina Ribbeck
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Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. [PDF]
, 2013 Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk of corneal infection, it is not known whether there is a direct causal relationship between ...
Evans, David +4 more
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Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile
BMC Genomics, 2011 Background Mucins are large glycoproteins implicated in protection of all mucosal surfaces. In humans and rodents, the mucin gene family has been well described and previous studies have investigated the distribution and function of mucins in the ...
Vercruysse Jozef +6 more
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Virulence, 2022 Carbohydrates can both protect against infection and act as targets promoting infection. Mucins are major components of the slimy mucus layer covering the fish epithelia.
John Benktander +4 more
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Prebiotics, faecal transplants and microbial network units to stimulate biodiversity of the human gut microbiome [PDF]
, 2013 Accumulating evidence demonstrates the intimate association between human hosts and the gut microbiome. Starting at birth, the sterile gut of the newborn acquires a diverse spectrum of microbes, needed for immunological priming.
Biasucci G. +7 more
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Arabinoxylans, inulin and Lactobacillus reuteri 1063 repress the adherent-invasive Escherichia coli from mucus in a musosa-comprising gut model [PDF]
, 2016 The microbiota that colonises the intestinal mucus may particularly affect human health given its proximity to the epithelium. For instance, the presence of the adherent-invasive Escherichia coli (AIEC) in this mucosal microbiota has been correlated with
De Weirdt, Rosemarie +6 more
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Airway Mucins Inhibit Oxidative and Non-Oxidative Bacterial Killing by Human Neutrophils
Frontiers in Pharmacology, 2020 Neutrophil killing of bacteria is mediated by oxidative and non-oxidative mechanisms. Oxidants are generated through the NADPH oxidase complex, whereas antimicrobial proteins and peptides rank amongst non-oxidative host defenses.
André M. Cantin +3 more
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Molecular and antigenic characterization of Trypanosoma cruzi TolT proteins [PDF]
, 2018 Background: TolT was originally described as a Trypanosoma cruzi molecule that accumulated on the trypomastigote flagellum bearing similarity to bacterial TolA colicins receptors.
Agüero, Fernan Gonzalo +13 more
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A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models [PDF]
, 2020 Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution.
Haase, Hajo, Maares, Maria
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
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