Results 61 to 70 of about 37,093 (292)

Mucin adhesion of serial cystic fibrosis airways Pseudomonas aeruginosa isolates

Frontiers in Cellular and Infection Microbiology
The chronic airway infections with Pseudomonas aeruginosa are the major co-morbidity in people with cystic fibrosis (CF). Within CF lungs, P. aeruginosa persists in the conducting airways together with human mucins as the most abundant structural ...
Christian Herrmann, Christian Herrmann, Meike Lingner, Meike Lingner, Susanne Herrmann, Susanne Herrmann, Inka Brockhausen, Burkhard Tümmler, Burkhard Tümmler, Burkhard Tümmler   +9 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Mucin expression patterns in histological grades of colonic cancers in Ghanaian population

The Pan African Medical Journal, 2017
INTRODUCTION: Myriad roles of mucins in normal tissues have been well documented, including lubrication of the epithelial surfaces; protection from physical damage; facilitation in cell-cell signaling and suppression of inflammatory activity ...
Kwabena Owusu Danquah, Ernest Adjei, Solomon Quayson, Ernest Adankwah, Daniel Gyamfi, Paul Poku Sampene Ossei, Gideon Dzikunu, Portia Mensah, Cecilia Lepkor   +8 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer

Cancer Management and Research, 2021
Hussain Almasmoum Laboratory Medicine Department, Faculty of Applied Medical Science, Umm Al-Qura University, Makkah, 7607, Saudi ArabiaCorrespondence: Hussain AlmasmoumLaboratory Medicine Department, Faculty of Applied Medical Science, Umm Al-Qura ...
Almasmoum H
doaj  

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

The inhibition of the Human Immunodeficiency Virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay

Virology Journal, 2008
Background The female reproductive tract is amongst the main routes for Human Immunodeficiency Virus (HIV) transmission. Cervical mucus however is known to protect the female reproductive tract from bacterial invasion and fluid loss and regulates and ...
Schoeman Leann, Tyler Marilyn G, Lotz Zoë E, de Beer Corena, Habte Habtom H, Kahn Delawir, Mall Anwar S   +6 more
doaj   +1 more source

Gel-forming and cell-associated mucins: Preparation for structural and functional studies

, 2011
Secreted and transmembrane mucins are important components of innate defence at the body's mucosal surfaces. The secreted mucins are large, polymeric glycoproteins, which are largely responsible for the gel-like properties of mucus secretions.
David J. Thornton, Davies, Julia, Thornton, David, Thornton, David,, Thornton, David J.; id_orcid, Wickström, Claes, Wickström, Claes,, Thornton, David J, Davies, Julia,, Davies, Julia R., Julia R. Davies, Claes Wickström   +11 more
core   +1 more source

Structural Alterations of Mucins Are Associated with Losses in Functionality

, 2021
Commercial mucin glycoproteins are routinely used as a model to investigate the broad range of important functions mucins fulfill in our bodies, including lubrication, protection against hostile germs, and the accommodation of a healthy microbiome ...
Crouzier, Thomas,, Vilaplana, Francisco,, Blakeley, Matthew,, Marczynski, Matthias,, Srivastava, Vaibhav,, Jiang, Kun,, Lieleg, Oliver,   +6 more
core   +1 more source