Results 91 to 100 of about 29,691,692 (162)

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration

EMBO Reports
Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization of organelles within cells, including endo-lysosomes, is a prerequisite of migration.
Philippe Dehio, Céline Michard, Juan Carlos Yam-Puc, Adrià-Arnau Martí i Líndez, Anett Jandke, Gunhild Unterstab, Lucien Fabre, Loïc Sauteur, Marc Artinger, Daniel F Legler, Michael Sixt, Thorsten Schaefer, Matthias P Wymann, Klaus Okkenhaug, Thierry Soldati, Matthias Mehling, Christoph Hess   +16 more
doaj   +1 more source

Autophagy-dependent lysosomal calcium overload and the ATP5B-regulated lysosomes-mitochondria calcium transmission induce liver insulin resistance under perfluorooctane sulfonate exposure

Ecotoxicology and Environmental Safety
Perfluorooctane sulfonate (PFOS), an officially listed persistent organic pollutant, is a widely distributed perfluoroalkyl substance. Epidemiological studies have shown that PFOS is intimately linked to the occurrence of insulin resistance (IR). However,
Jixun Li, Yu Ma, Tianming Qiu, Jianyu Wang, Jingyuan Zhang, Xiance Sun, Liping Jiang, Qiujuan Li, Xiaofeng Yao   +8 more
doaj   +1 more source

Palmitate impairs autophagic degradation via oxidative stress/perilysosomal Ca2+ overload/mTORC1 activation pathway in pancreatic β cells

JCI Insight
Saturated fatty acids impose lipotoxic stress on pancreatic β cells, leading to β cell failure and diabetes. In this study, we investigate the critical role of organellar Ca2+ disturbance on defective autophagy and β cell lipotoxicity.
Ha Thu Nguyen, Luong Dai Ly, Thuy Thi Thanh Ngo, Soo Kyung Lee, Carlos Noriega Polo, Subo Lee, Taesic Lee, Seung-Kuy Cha, Xaviera Riani Yasasilka, Kae Won Cho, Myung-Shik Lee, Andreas Wiederkehr, Claes B. Wollheim, Kyu-Sang Park   +13 more
doaj   +1 more source

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science
Lysosomal exocytosis, a calcium‐dependent secretory process, facilitates extracellular release of cargos that promote cancer progression, though its regulatory pathways and therapeutic strategies are poorly understood.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
doaj   +1 more source

Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes

Virulence
Coxiella burnetii (C. burnetii) is the causative agent of Q fever, a zoonotic disease. Intracellular replication of C. burnetii requires the maturation of a phagolysosome-like compartment known as the replication permissive Coxiella-containing vacuole ...
Mingliang Zhao, Shan Zhang, Weiqiang Wan, Chunyu Zhou, Nana Li, Ruxi Cheng, Yonghui Yu, Xuan Ouyang, Dongsheng Zhou, Jun Jiao, Xiaolu Xiong   +10 more
doaj   +1 more source

LAMTOR1 regulates dendritic lysosomal positioning in hippocampal neurons through TRPML1 inhibition

Frontiers in Cellular Neuroscience
Intracellular lysosomal trafficking and positioning are fundamental cellular processes critical for proper neuronal function. Among the diverse array of proteins involved in regulating lysosomal positioning, the Transient Receptor Potential Mucolipin 1 ...
Jiandong Sun, Weiju Lin, Xiaoning Hao, Michel Baudry, Xiaoning Bi   +4 more
doaj   +1 more source

Role of the lysosomal channel Transient Receptor Potential Mucolipin 1 (TRPML1) in the functional coupling between endoplasmic reticulum and lysosomes in experimental models of brain ischemia [PDF]

, 2018
A growing interest has been recently devoted to the role of intracellular Ca2+ stores in brain ischemia. For instance, disturbances of Ca2+ content in the endoplasmic reticulum (ER), the main intracellular Ca2+ store, have been reported as one of the main mechanisms underlying this neurological disease.
openaire   +1 more source

Lysosomal iron accumulation and subsequent lysosomes-mitochondria iron transmission mediate PFOS-induced hepatocyte ferroptosis

Ecotoxicology and Environmental Safety
Perfluorooctane sulfonate (PFOS) is known as a persistent organic pollutant. A significant correlation between PFOS and liver ferroptosis has been unveiled, but the precise mechanism needs to be elucidated. In prior research, we found that PFOS treatment
Jixun Li, Ruzhen Feng, Wei Yang, Peiyao Liang, Tianming Qiu, Jingyuan Zhang, Xiance Sun, Qiujuan Li, Guang Yang, Xiaofeng Yao   +9 more
doaj   +1 more source

Mucolipin 1 (MCOLN1; ML4) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Mucolipin 1 (TRPML1; MCOLN1) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source