Results 81 to 90 of about 29,691,692 (162)
Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
Communications BiologyTranscription Factor EB (TFEB) controls lysosomal biogenesis and autophagy in response to nutritional status and other stress factors. Although its regulation by nuclear translocation is known to involve a complex network of well-studied regulatory ...
Iacopo Ruolo +5 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background and Aims Dengue fever is mostly found in tropical and subtropical regions and is spread by mosquitoes. Still now, no specific antiviral medication is available against the disease. However, several vitamins have been identified as potential dengue therapy supplements. Therefore, this study aimed to comprehensively gather data on the
Shah Md Muztahid Hasan Chowdhury +6 more
wiley +1 more source
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
PLoS PathogensViral infection is a significant risk factor for fertility issues. Here, we demonstrated that infection by neurotropic alphaherpesviruses, such as pseudorabies virus (PRV), could impair female fertility by disrupting the hypothalamus-pituitary-ovary axis
Bing-Qian Su +4 more
doaj +1 more source
Visualization of lysosomal membrane proteins by cryo electron tomography
Nature CommunicationsLysosomes are essential organelles for cellular homeostasis and signaling, with dysfunction linked to neurological disorders, lysosomal storage diseases, and cancer. While proteomics has advanced our understanding of lysosomal composition, the structural
Bridget M. McVeigh +7 more
doaj +1 more source
ZnT3 expression levels are down-regulated in the brain of Mcoln1 knockout mice
Molecular Brain, 2019 Aim Zinc is a critical divalent cation in mammalian brain, but its concentration must be strictly-controlled. Within certain subsets of glutamatergic neurons, ZnT3 (encoded by the Slc30a3 gene) facilitates the transport and storage of zinc in synaptic ...
Jonathan Chacon +2 more
doaj +1 more source
Iron dysregulation in movement disorders
Neurobiology of Disease, 2012 Iron is an essential element necessary for energy production, DNA and neurotransmitter synthesis, myelination and phospholipid metabolism. Neurodegeneration with brain iron accumulation (NBIA) involves several genetic disorders, two of which ...
Petr Dusek, Joseph Jankovic, Weidong Le
doaj +1 more source
Cell Reports, 2019 Summary: We screen ion channels and transporters throughout the genome to identify those required by human melanoma cells but not by normal human melanocytes.
Stacy Y. Kasitinon +9 more
doaj +1 more source
TRPML1 gating modulation by allosteric mutations and lipids
eLifeTransient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV).
Ninghai Gan +3 more
doaj +1 more source
Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry.
Long Denggao +4 more
core +1 more source