Results 61 to 70 of about 29,691,692 (162)

BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock, Laura Heitzer, Joana Massa, Marvin Taterra, Marcel Bermúdez, Oliver Koch, Matthias Schiedel   +6 more
wiley   +1 more source

Loss of Lysosomal Ion Channel Transient Receptor Potential Channel Mucolipin-1 (TRPML1) Leads to Cathepsin B-dependent Apoptosis [PDF]

Journal of Biological Chemistry, 2012
Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the gene MCOLN1, which codes for the transient receptor potential family ion channel TRPML1. MLIV has an early onset and is characterized by developmental delays, motor and cognitive deficiencies, gastric abnormalities, retinal degeneration, and corneal cloudiness.
Grace A, Colletti, Mark T, Miedel, James, Quinn, Neel, Andharia, Ora A, Weisz, Kirill, Kiselyov   +5 more
openaire   +2 more sources

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum

Cell Biology International, Volume 50, Issue 9, September 2026.
ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Sarah Abdulaziz Alamer
wiley   +1 more source

Chronic Contractile Activity Remediates Lysosomal Dysfunction in a Muscle Cell Lysosomal Disease Model

Journal of Cellular Physiology, Volume 241, Issue 9, September 2026.
Bafilomycin A1‐induced lysosomal dysfunction can be mitigated by CCA in muscle myotubes. The curcumin analogue C1 similarly decreases lysosomal accumulation, modestly improves function and increases mitochondrial content, suggesting that both CCA and C1 may represent potential strategies for alleviating lysosomal dysfunction and supporting muscle cell ...
Debasmita Bhattacharya, Neushaw Moradi, David A. Hood   +2 more
wiley   +1 more source

Change of transcription factor EB activity and autophagy in hippocampus of type 2 diabetic encephalopathy mice

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the changes of transcription factor EB (TFEB), the activity of the upstream proteins and autophagy in the hippocampus of mice with type 2 diabetic encephalopathy.Methods·Twenty healthy 8-week-old male C57BL/6J mice were randomly ...
CHEN Yixin, CHENG Lizhen, LIN Yijia, MIAO Ya   +3 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Targeting PIKfyve: Chemical Biology and Drug Discovery Insights

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
PIKfyve inhibitors have progressed from niche chemical probes to powerful tools for interrogating endolysosomal biology, enabled by rapid and robust cellular phenotypes. Compounds such as apilimod establish PIKfyve as a druggable lipid kinase, while agents like vacuolin‐1 underscore the importance of distinguishing true target engagement from ...
Athavan Alias Anand Selvam, Anamika Sharma   +1 more
wiley   +1 more source

TRPML1 Controls Mitochondrial Homeostasis and Alleviates Cardiac Hypertrophy by Inhibiting VDAC1 Oligomerization

Engineering
The preservation of mitochondrial homeostasis plays a critical role in preventing the progression of pathological cardiac hypertrophy to heart failure (HF).
Xiuye Zhao, Mingxiu Zhang, Changling Lv, Chunlei Duan, Zhen Chen, Yan Hao, Zhen Liang, Yiping Tao, Hongda Li, Zhenru Wang, Haonan Du, Jiapan Wang, Wenjie Liao, Peifeng Li, Jia Wang, Xueqi He, Yu Zhang, Xinyuan Hao, Hongyu Ji, Yan Zhang, Xingda Li, Ye Yuan, Zhimin Du   +22 more
doaj   +1 more source

Defect and Rescue of NAADP‐activated Ca2+ Channel Activity in Mucolipin‐1 Deficient Human Fibroblasts

The FASEB Journal, 2008
Recent studies have indicated that mucolipin‐1 (TRP‐ML1) may be a lysosomal Ca 2+ channel activated by a novel Ca 2+ signaling nucleotide, NAADP. The present study attempted to further test the hypothesis that NAADP functions as an endogenous activator ...
Fan Zhang, Si Jin, Fan Yi, Cindy Thomas, Pin‐Lan Li   +4 more
openaire   +1 more source