Results 91 to 100 of about 45,948 (240)

Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diets⃞

Journal of Lipid Research, 2006
Stearoyl-coenzyme A desaturase 1-deficient (SCD1−/−) mice have impaired MUFA synthesis. When maintained on a very low-fat (VLF) diet, SCD1−/− mice developed severe hypercholesterolemia, characterized by an increase in apolipoprotein B (apoB)-containing ...
Matthew T. Flowers, Albert K. Groen, Angie Tebon Oler, Mark P. Keller, YounJeong Choi, Kathryn L. Schueler, Oliver C. Richards, Hong Lan, Makoto Miyazaki, Folkert Kuipers, Christina M. Kendziorski, James M. Ntambi, Alan D. Attie   +12 more
doaj   +1 more source

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

Association between substituting macronutrients and all-cause mortality: a network meta-analysis of prospective observational studiesResearch in context

EClinicalMedicine
Summary: Background: Suboptimal diet quality is a key risk factor for premature death. Assuming relatively stable energy intake among individuals, changes in nutrient intakes occur by exchanging different nutrients.
Sabina Wallerer, Theodoros Papakonstantinou, Jakub Morze, Julia Stadelmaier, Eva Kiesswetter, Lea Gorenflo, Janett Barbaresko, Edyta Szczerba, Manuela Neuenschwander, William Bell, Tilman Kühn, Szimonetta Lohner, Marta Guasch-Ferré, Georg Hoffmann, Joerg J. Meerpohl, Sabrina Schlesinger, Adriani Nikolakopoulou, Lukas Schwingshackl   +17 more
doaj   +1 more source

Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease[S]

Journal of Lipid Research, 2010
Dietary fatty acids are major contributors to the development and progression of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Dietary fatty acids also alter hepatic NKT cells that are activated by antigens presented by CD1d.
Jing Hua, Xiong Ma, Tonya Webb, James J. Potter, Mathias Oelke, Zhiping Li   +5 more
doaj   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Fat quality in the indigenous Krškopolje pig reared in an enriched environment

Acta Agriculturae Slovenica, 2014
The search for fat composition and content that is favourable in intramuscular fat (IMF) for fresh meat quality and at the same time in subcutaneous adipose tissue (SCF) for processed meat products, within the same breed, is reflected in the growing ...
Marjeta ŽEMVA, Tania M. NGAPO, Špela MALOVRH, Alenka LEVART, Milena KOVAČ   +4 more
doaj   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Effects of a multifactorial ecosustainable isocaloric diet on liver fat in patients with type 2 diabetes: randomized clinical trial

BMJ Open Diabetes Research & Care, 2020
Introduction Treatment options for non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2D) are still a matter of debate. We compared the effects of a diet including different components versus a proven beneficial diet rich in ...
Giuseppe Della Pepa, Claudia Vetrani, Valentina Brancato, Marilena Vitale, Serena Monti, Giovanni Annuzzi, Gianluca Lombardi, Anna Izzo, Marianna Tommasone, Paola Cipriano, Gennaro Clemente, Peppino Mirabelli, Marcello Mancini, Marco Salvatore, Gabriele Riccardi, Angela Albarosa Rivellese, Lutgarda Bozzetto   +16 more
doaj   +1 more source

Changes in body composition and fatty acid profile during embryogenesis of quillback rockfish (Sebastes maliger) [PDF]

, 2009
We investigated developmental changes in the body compositions and fatty acid (FA) profiles of embryos and preparturition larvae of the quillback rockfish (Sebastes maliger).
Rodgveller, Cara A., Sewall, Fletcher F.
core  

Bleomycin-induced trans lipid formation in cell membranes and in liposome models [PDF]

, 2015
Cell cultures of NTera-2 cells incubated with bleomycin and liposomes as biomimetic models of cell membranes were used for examining some novel aspects of drug-metal induced reactivity with unsaturated lipids under oxidative conditions. In cell cultures,
Barata Vallejo, Sebastian, Chatgilialoglu, Chryssostomos, Cort, Aysegul, Ferreri, Carla, Ozben, Tomris, Sansone, Anna   +5 more
core   +1 more source