Results 61 to 70 of about 45,948 (240)

WDTC1, the Ortholog of Drosophila Adipose Gene, Associates With Human Obesity, Modulated by MUFA Intake [PDF]

Obesity, 2009
Adipose (adp) is an obesity gene in Drosophila and mice with crucial functions in fat metabolism. We investigated the correlation between genetic variation of the WDTC1 locus, the ortholog of adp, and human obesity. Five WDTC1 single‐nucleotide polymorphisms (SNPs) were genotyped in 935 and 1,115 adults of two ethnically diverse US populations.
Chao-Qiang, Lai, Laurence D, Parnell, Donna K, Arnett, Bibiana, García-Bailo, Michael Y, Tsai, Edmond K, Kabagambe, Robert J, Straka, Michael A, Province, Ping, An, Ingrid B, Borecki, Katherine L, Tucker, José M, Ordovás   +11 more
openaire   +2 more sources

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation

Advanced Science, EarlyView.
The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley   +1 more source

Repeatability and validity of a food frequency questionnaire in free-living older people in relation to cognitive function [PDF]

, 2008
Objectives: To determine the repeatability and validity of a self-administered, 175-item food frequency questionnaire (FFQ) in free-living older people and to assess whether these are influenced by cognitive function.
Aucott, Lorna S, Craig, Leone CA, Jia, Xueli, McNeill, Geraldine, Milne, Anne C   +4 more
core  

Potentials to differentiate milk composition by different feeding strategies [PDF]

, 2009
To investigate the effect of the dietary intake of the cow on milk composition, bulk-tank milk was collected on 5 occasions from conventional (n = 15) and organic (n = 10) farms in Denmark and on 4 occasions from low-input nonorganic farms in the United ...
Butler, G., Kristensen, T., Leifert, C., Nielsen, J.H., Skibsted, L.H., Slots, T.   +5 more
core   +1 more source

Prostate cancer diagnosis and management: current practices in Africa a consultant-based survey

Frontiers in Urology
IntroductionIn Africa, prostate cancer poses significant diagnostic and treatment challenges due to limited access to diagnostic tools and healthcare resources. This survey aimed to assess current prostate biopsy practices, patient classification methods,
Marcella Derboise Christelle Biyouma, Marcella Derboise Christelle Biyouma, Kaleab Habtemichael Gebreselassie, Kaleab Habtemichael Gebreselassie, Saleh Abdelkerim Nedjim, Saleh Abdelkerim Nedjim, Ouima Justin Dieudonné Ziba, Ouima Justin Dieudonné Ziba, Axel Stéphane Nwaha Makon, Axel Stéphane Nwaha Makon, Anteneh Tadesse Kifle, Anteneh Tadesse Kifle, Taofiq Olayinka Mohammed, Ayun Kotokai Cassell, Bencherki Youssef, Bencherki Youssef, Sissoko Idrissa, Orgeness Jasper Mbwambo, Orgeness Jasper Mbwambo, Mahamat Ali Mahamat, Rachid Aboutaieb, Tagang Titus Ngwa‐Ebogo, Alain Khassim Ndoye, Emiola Oluwabunmi Olapade-Olaopa, Fru Fobuzshi Angwafo, Fru Fobuzshi Angwafo   +25 more
doaj   +1 more source

Chemometric modelling to relate antioxidants, neutral lipid fatty acids and flavour components in chicken breast [PDF]

, 2005
Relationships among quality factors in retailed free-range, corn-fed, organic, and conventional chicken breasts (9) were modeled using chemometric approaches.
Jahan, K., Paterson, A., Piggott, J., Spickett, C.   +3 more
core  

Video and Text‐Based Supplemental Health Information and Consumer Willingness to Pay for Nutrient‐Enhanced Eggs

Agribusiness, EarlyView.
ABSTRACT Nutritional information is very important in the food choices of consumers. However, when they are too scientific or technical, they have the potential to confuse consumers, resulting in information asymmetry and dissuading them from making beneficial choices.
Edeoba W. Edobor, Michael J. Best, Anita R. Best, Ondulla T. Toomer   +3 more
wiley   +1 more source

Summer Annual x Fertility Rate Trial [PDF]

, 2012
Warm season grasses are high yield and quality forages best grown during the hot and dry summer months. They can provide quality pasture in the summer months when common cool season grasses are not as productive. Warm season grasses can also be harvested
Burke, Conner, Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Rosalie, Monahan, Susan   +5 more
core   +1 more source