Results 61 to 70 of about 326,606 (317)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

TopoMAS: Large Language Model Driven Topological Materials Multi‐Agent System

open access: yesMaterials Genome Engineering Advances
ABTRACT The discovery of topological materials is severely hampered by fragmented research workflows that cause information loss, inconsistent reasoning, and frequent computational failures.
Baohua Zhang   +5 more
doaj   +1 more source

Cloud Computing and Multi Agent System to improve Learning Object Paradigm [PDF]

open access: yesInteraction Design and Architecture(s), 2015
The paradigm of Learning Object provides Educators and Learners with the ability to access an extensive number of learning resources. To do so, this paradigm provides different technologies and tools, such as federated search platforms and storage ...
Ana B. Gil   +2 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Sistem Load Balancing Menggunakan Least Time First Byte dan Multi Agent System

open access: yesJurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017
Network activity has increased in every year due to rapid growth of internet users. This phenomenon eventually increases the load server. The high load on server makes server down.
Muhammad Faizal Afriansyah   +2 more
doaj   +1 more source

Enhancement of Neural Network Based Multi Agent System for Classification and Regression in Energy System

open access: yesIEEE Access, 2020
Extreme Learning Machine improved the iterative procedures of adjusting weights by randomly selecting hidden neurons besides analytically determining the output weights.
Chong Tak Yaw   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

An Adaptive Normative Multi Agent System using Web 3.0 for e-Learning Platform

open access: yesOnline Academic Journal of Information Technology, 2013
The growing concern for education and innovative technologies has led to a new dimension of learning. The paper proposes a new framework NormATel using the concept of Normative Multi-Agent system, Activity Theory and e-Learning.
.ımran Ali Siddiqu   +3 more
doaj   +1 more source

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