Results 61 to 70 of about 20,520,278 (241)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Trust in multi-agent systems [PDF]

open access: yesThe Knowledge Engineering Review, 2004
Trust is a fundamental concern in large-scale open distributed systems. It lies at the core of all interactions between the entities that have to operate in such uncertain and constantly changing environments. Given this complexity, these components, and the ensuing system, are increasingly being conceptualised, designed, and built using agent-based ...
Sarvapali D. Ramchurn   +2 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

HIERARCHICAL STRUCTURE OF A MULTI-AGENT SYSTEM

open access: yesИзмерение, мониторинг, управление, контроль, 2022
Background. Improving the efficiency of data collection and processing is necessary to ensure guaranteed trouble-free operation of information-measuring and control systems.
O.E. Bezborodova
doaj   +1 more source

A Multi-Agent Recommender System

open access: yes, 2012
The large amount of pages in Websites is a problem for users who waste time looking for the information they really want. Knowledge about users’ previous visits may provide patterns that allow the customization of the Website. This concept is known as Adaptive Website: a Website that adapts itself for the purpose of improving the user’s experience ...
António Jorge Morais   +2 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

AF-ABLE in the Multi Agent Contest 2009 [PDF]

open access: yes, 2009
Entry in the Multi-Agent Contest 2009, at the 10th International Workshop on Computational Logic in Multi-Agent Systems (CLIMA-X), 9-10th September, HamburgThis is the second year in which a team from University College Dublin has participated in the ...
Lillis, David   +6 more
core   +1 more source

Sistem Load Balancing Menggunakan Least Time First Byte dan Multi Agent System

open access: yesJurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017
Network activity has increased in every year due to rapid growth of internet users. This phenomenon eventually increases the load server. The high load on server makes server down.
Muhammad Faizal Afriansyah   +2 more
doaj   +1 more source

Formalisms for multi-agent systems [PDF]

open access: yesThe Knowledge Engineering Review, 1997
As computer scientists, our goals are motivated by the desire to improve computer systems in some way: making them easier to design and implement, more robust and less prone to error, easier to use, faster, cheaper, and so on. In the field of multi-agent systems, our goal is to build systems capable of flexible autonomous decision making, with ...
Mark d'Inverno   +6 more
openaire   +3 more sources

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