Results 1 to 10 of about 136,187 (283)

Characteristics of DNA macro-alterations in breast cancer with liver metastasis before treatment

BMC Genomics, 2023
Background Whole-genome doubling (WGD) has been observed in 30% of cancers, followed by a highly complex rearranged karyotype unfavourable to breast cancer's outcome.
Yu Fan, Linglin Zou, Xiaorong Zhong, Zhu Wang, Yu Wang, Chuanxu Luo, Hong Zheng, Yanping Wang   +7 more
doaj   +1 more source

Epidemiologic characteristics of high-risk HPV and the correlation between multiple infections and cervical lesions

BMC Infectious Diseases, 2023
Background The aim of this study was to determine the prevalence of high-risk human papillomavirus (HR-HPV) and the correlation between multiple infections and cervical lesions.
Qinli Luo, Xianghua Zeng, Hanyi Luo, Ling Pan, Ying Huang, Haiyan Zhang, Na Han   +6 more
doaj   +1 more source

Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set

Annals of Human Biology, 2022
Background The analysis of Y chromosomal genetic markers is of great significance in human genetic fields related to male individuals. The Han nationality is the most populous ethnic group.
Hui Xu, Ming Zhao, Shuyan Mei, Yunying Zhang, Meiming Cai, Fanzhang Lei, Bofeng Zhu   +6 more
doaj   +1 more source

Multiple genetic analyses for Chinese Hunan Han population via 46 A-STRs

Annals of Human Biology, 2022
Background Short tandem repeats (STRs) are important as common genetic markers in forensic identification and population genetics due to their highly polymorphic nature.
Yunying Zhang, Yating Fang, Man Chen, Ming Zhao, Hui Xu, Congying Zhao, Jiangwei Lan, Bofeng Zhu   +7 more
doaj   +1 more source

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. [PDF]

, 2022
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated ...
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium, COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk   +1 more
core   +1 more source

Microbial community succession in the intestine of mice with deep partial-thickness burns

Frontiers in Microbiology, 2023
IntroductionBurn injury has been shown to lead to changes in the composition of the gut microbiome and cause other damage in patients. However, little is known about how the gut microbial community evolves in individuals who have recovered from burn ...
Li-Jian Chen, Yi Liu, Jing-Wen Yang, Yan Lin, Clare Hsu, Kai-Kai Zhang, Jia-Li Liu, Jia-Hao Li, Xiu-Wen Li, Jian-Zheng Yang, Long Chen, Jia-Hao Zeng, Xiao-Li Xie, Jing-Tao Xu, Qi Wang   +14 more
doaj   +1 more source

Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

Journal of Hematology & Oncology, 2020
Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway.
Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong, Yun Ge, Chul Soon Yong, Jong Oh Kim, Jong-Sup Bae, Im-Sook Song, In-San Kim, You Mie Lee   +10 more
doaj   +1 more source

Putting Proteomics Into Immunotherapy for Glioblastoma

Frontiers in Immunology, 2021
In glioblastoma, the most aggressive brain cancer, a complex microenvironment of heterogeneity and immunosuppression, are considerable hurdles to classify the subtypes and promote treatment progression. Treatments for glioblastoma are similar to standard
Liangyu Chen, Di Qin, Xinyu Guo, Qixue Wang, Qixue Wang, Jie Li   +5 more
doaj   +1 more source

Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine [PDF]

, 2020
Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study.
Kang, Yun Pyo, Kim, Hyung Min, Kwon, Sung Won, NGHI, TRAN, Nguyen Hoang Anh, Nguyen Phuoc Long, PARK, SANG KI   +6 more
core   +1 more source

The Personal Genome Project-UK, an open access resource of human multi-omics data [PDF]

, 2019
Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicated by the fact that the raw sequencing output
Beck, Stephan, Berner, Alison, Chervova, Olga, Conde, Lucia, Guerra-Assunção, José Afonso, Hamoudi, Rifat, Herrero, Javier, Jesus, Tiago F., Larose Cadieux, Elizabeth, Moghul, Ismail, Tian, Yuan, Voloshin, Vitaly, Webster, Amy P.   +12 more
core   +2 more sources