Results 31 to 40 of about 136,187 (283)
Unconventional machine learning of genome-wide human cancer data
, 2020 Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective ...
Bajaj, Sweta R. +7 more
core +1 more source
Multi-omics approaches to disease
Genome Biology, 2017 High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field of "integrative genetics".
Hasin, Yehudit +2 more
openaire +5 more sources
Acta Pharmaceutica Sinica B, 2023 Methamphetamine (Meth) abuse can cause serious mental disorders, including anxiety and depression. The gut microbiota is a crucial contributor to maintaining host mental health. Here, we aim to investigate if microbiota participate in Meth-induced mental
Kaikai Zhang +11 more
doaj +1 more source
Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli. [PDF]
, 2016 A significant obstacle in training predictive cell models is the lack of integrated data sources. We develop semi-supervised normalization pipelines and perform experimental characterization (growth, transcriptional, proteome) to create Ecomics, a ...
Kim, Minseung +3 more
core +2 more sources
Pharmacoproteomic characterisation of human colon and rectal cancer [PDF]
, 2017 Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge.
Domingo, Enric +19 more
core +1 more source
Establishment of a integrative multi-omics expression database CKDdb in the context of chronic kidney disease (CKD) [PDF]
, 2017 Complex human traits such as chronic kidney disease (CKD) are a major health and financial burden in modern societies. Currently, the description of the CKD onset and progression at the molecular level is still not fully understood.
Fernandes, Marco, Husi, Holger
core +1 more source
Annals of Medicine, 2023 Background The mechanism of Venous thromboembolism (VTE) is complicated and difficult to prevent due to factors such as bone marrow invasion, therapy, and immune-mediated effects.
Guanzhong Liang +7 more
doaj +1 more source
Structured penalized regression for drug sensitivity prediction
, 2020 Large-scale {\it in vitro} drug sensitivity screens are an important tool in personalized oncology to predict the effectiveness of potential cancer drugs.
Zhao, Zhi, Zucknick, Manuela
core +1 more source
Kronos: a workflow assembler for genome analytics and informatics. [PDF]
, 2017 BackgroundThe field of next-generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized.
Aniba, Radhouane +9 more
core +1 more source
Frontiers in Oncology, 2023 IntroductionExcess copper induces cell death by binding to lipoylated components of the tricarboxylic acid cycle. Although a few studies have examined the relationship between cuproptosis-related genes (CRGs) and breast cancer prognosis, reports on ...
Yu Fan +10 more
doaj +1 more source