Results 41 to 50 of about 136,187 (283)

Transkingdom Networks: A Systems Biology Approach to Identify Causal Members of Host-Microbiota Interactions

, 2017
Improvements in sequencing technologies and reduced experimental costs have resulted in a vast number of studies generating high-throughput data. Although the number of methods to analyze these "omics" data has also increased, computational complexity ...
A Fuente de la, A Morgun, A Morgun, A Mortazavi, A Perez-Diez, A Yambartsev, AR Erickson, AR Joyce, B Buchfink, B Langmead, BJ Haas, C Trapnell, CL Poirel, CL Schoch, DH Huson, DJ Lane, DJ McCarthy, E Saccenti, E Stackebrandt, ER Mardis, F Imhann, F Meyer, Gautier, J Kuczynski, J Skinner, JG Caporaso, JL Brookman, JN Paulson, KL Mine, LD Thomas, M Martin, M Schirmer, MA Moreno-Risueno, ML Metzker, N Gehlenborg, N Krumm, N Segata, N Shulzhenko, O Morozova, P Li, PD Schloss, PW Laird, R Greer, R Schmieder, Ritchie, RL Greer, RR Rodrigues, S Anders, S Goodwin, S Lindgreen, S Weiss, S Zhao, SC Schuster, TJ Sharpton, W Zhang, X Dong, YJ Hua   +56 more
core   +1 more source

Unveiling the genetic landscape of high-altitude adaptive ethnic groups with polymorphic markers: Implications of comprehensive forensic appraisals and population genetic investigations

Heliyon, 2023
Background: Deletion/insertion polymorphisms (DIPs), a novel class of biomarker, have been widely utilized in forensic areas for individual identification, paternity tests, and ancestral origin inference due to its applicability to degraded samples and ...
Ming Zhao, Wei Cui, Hui Xu, Yunying Zhang, Bofeng Zhu   +4 more
doaj   +1 more source

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and ...
Goldenberg, Anna, Hoffman, Michael M., Leskovec, Jure, Nguyen, Francis, Wang, Bo, Zitnik, Marinka   +5 more
core   +1 more source

On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches [PDF]

, 2019
The need to facilitate the complex management of cardiometabolic diseases (CMD) has led to the detection of many biomarkers, however, there are no clear explanations of their role in the prevention, diagnosis or prognosis of these diseases.
Argano, Vincenzo, Balistreri, Carmela Rita, Giarratana, Rosa Maria, Lio, Domenico, Scola, Letizia, Torre, Salvatore   +5 more
core   +1 more source

Heterogeneity in pure microbial systems: experimental measurements and modeling [PDF]

, 2017
Cellular heterogeneity influences bioprocess performance in ways that until date are not completely elucidated. In order to account for this phenomenon in the design and operation of bioprocesses, reliable analytical and mathematical descriptions are ...
González-Cabaleiro, Rebeca, Mitchell, Anca M., Ofiţeru, Irina D., Smith, Wendy, Wipat, Anil   +4 more
core   +2 more sources

Multi-Omics factor analysis - a framework for unsupervised integration of multi-omic data sets

Molecular Systems Biology, 2017
AbstractMulti-omic studies promise the improved characterization of biological processes across molecular layers. However, methods for the unsupervised integration of the resulting heterogeneous datasets are lacking. We present Multi-Omics Factor Analysis (MOFA), a computational method for discovering the principal sources of variation in multi-omic ...
Argelaguet, Ricard, Velten, Britta, Arnol, Damien, Dietrich, Sascha, Zenz, Thorsten, Marioni, John C, Buettner, Florian, Huber, Wolfgang, Stegle, Oliver   +8 more
openaire   +6 more sources

Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

Communications Medicine
Background Age and sex significantly impact DNA methylation patterns, however, existing datasets typically include only a subset of methylation sites in the human genome, hindering our thorough understanding.
Wei Chen, Jinjin Xu, Guodan Zeng, Rijing Ou, Changlin Yang, Chuang Xu, Yeqin Wang, Xinxin Wang, Qiuyan Li, Chenhui Zhao, Wenwen Zhou, Yu Lin, Wending Pang, Haiqiang Zhang, Jianhua Yin, Yan Zhang, Xin Jin   +16 more
doaj   +1 more source

An interpretation of the genetic polymorphism and population genetic background of Ankang Han population via a novel InDel panel

Forensic Sciences Research, 2021
In this research, genotyping data of 43 InDel loci in 311 Han individuals in Ankang city, Shaanxi province, China were detected using a self-developed five-dye multiplex amplification panel.
Wei Cui, Xiaoye Jin, Yating Fang, Qiong Lan, Jiangwei Lan, Man Chen, Shuyan Mei, Tong Xie, Bofeng Zhu   +8 more
doaj   +1 more source

Genetic polymorphisms and population genetic analyses of 57 autosomal InDel loci in Hubei Tujia group

Frontiers in Genetics, 2023
Introduction: The Tujia is the eighth most populous population in China, but its genetic structure has not been fully studied.Methods: In this study, we utilized 57 autosomal Insertion/deletion (InDel) loci to evaluate the genetic polymorphisms and ...
Jiangwei Lan, Xingru Zhang, Wei Cui, Shuyan Mei, Jingtao Xu, Bofeng Zhu   +5 more
doaj   +1 more source

The Computational Diet: A Review of Computational Methods Across Diet, Microbiome, and Health. [PDF]

, 2020
Food and human health are inextricably linked. As such, revolutionary impacts on health have been derived from advances in the production and distribution of food relating to food safety and fortification with micronutrients. During the past two decades,
Eetemadi, Ameen, Kim, Minseung, Pereira, Beatriz Merchel Piovesan, Rai, Navneet, Schmitz, Harold, Tagkopoulos, Ilias   +5 more
core