Results 71 to 80 of about 136,187 (283)

jMorp: Japanese Multi Omics Reference Panel [PDF]

Nucleic Acids Research, 2017
We developed jMorp, a new database containing metabolome and proteome data for plasma obtained from >5000 healthy Japanese volunteers from the Tohoku Medical Megabank Cohort Study, which is available at https://jmorp.megabank.tohoku.ac.jp. Metabolome data were measured by proton nuclear magnetic resonance (NMR) and liquid chromatography-mass ...
Shu Tadaka, Daisuke Saigusa, Ikuko N Motoike, Jin Inoue, Yuichi Aoki, Matsuyuki Shirota, Seizo Koshiba, Masayuki Yamamoto, Kengo Kinoshita   +8 more
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. [PDF]

, 2019
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular,
Ajami, Nadim J, Ananthakrishnan, Ashwin N, Andrews, Elizabeth, Arze, Cesar, Avila-Pacheco, Julian, Bonham, Kevin S, Braun, Jonathan, Brislawn, Colin J, Casero, David, Clish, Clary B, Courtney, Holly, Denson, Lee A, Franzosa, Eric A, Gonzalez, Antonio, Graeber, Thomas G, Hall, A Brantley, Huttenhower, Curtis, IBDMDB Investigators, Jansson, Janet K, Knight, Rob, Kugathasan, Subra, Lake, Kathleen, Landers, Carol J, Lloyd-Price, Jason, Mallick, Himel, McGovern, Dermot PB, Petrosino, Joseph F, Plichta, Damian R, Poon, Tiffany W, Prasad, Mahadev, Rahnavard, Gholamali, Sauk, Jenny, Schirmer, Melanie, Shungin, Dmitry, Stappenbeck, Thaddeus S, Vlamakis, Hera, Vázquez-Baeza, Yoshiki, White, Richard A, Winter, Harland S, Xavier, Ramnik J   +39 more
core  

Integrative Multi-Omics Data-Driven Approach for Metastasis Prediction in Cancer [PDF]

, 2018
[Abstract] Nowadays biomedical research is generating huge amounts of omic data, covering all levels of genetic information from nucleotide sequencing to protein metabolism.
Dorado, Julián, Fernández-Lozano, Carlos, Gestal, M., Liñares Blanco, José, Pazos, A.   +4 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Chromatin dynamics and regulatory drivers of hypoplastic hepatic progenitor cells in partial hepatectomy model

Communications Biology
The remarkable plasticity of hepatocytes underlies diverse roles in distinct patterns of liver injury. Specifically, hepatocyte-derived progenitor cells play dominant roles in driving the regenerative response during chronic liver injury.
Yan Wu, Shenglong Li, Hong Wu, Jiahui Luo, Qiuting Deng, Yue Yuan, Pengcheng Guo, Shuncheng Shangguan, Yiwei Lai, Xiaoyu Wei, Ying Gu, Xin Liu, Longqi Liu, Chuanyu Liu, Tao Yang, Jiangshan Xu, Shijie Hao   +16 more
doaj   +1 more source

Forensic Characteristics and Genetic Background Dissections of Chinese Manchu and Zhuang Groups Using 59 Autosomal Diallelic InDels and 2 miniSTRs

Frontiers in Bioscience-Landmark, 2022
Background: The latest development in molecular biology has offered an opportunity to construct multiplex panel with better applicability for forensic purpose, and a self-developed 64-plex panel, including 59 autosomal diallelic InDels, 2 miniSTRs, 2 Y ...
Fanzhang Lei, Meiming Cai, Shengjie Nie, Hui Xu, Qiong Lan, Xiaole Bai, Bofeng Zhu   +6 more
doaj   +1 more source

Genetic landscape of multiple sclerosis susceptibility by leveraging multi-omics data [PDF]

, 2018
The main objective of the research studies presented in this thesis is to study the genetic variants and the expression of genes that relate to Multiple Sclerosis (MS).
James, Tojo
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Tracing the tissue origin of cell-free DNA through open chromatin footprint

Communications Biology
Plasma cell-free DNA (cfDNA) is a promising biomarker for liquid biopsy, essential for diagnosing and monitoring diseases. Current methods for estimating tissue contributions primarily rely on methylation markers, which can damage cfDNA, limiting ...
Lingguo Li, Xiameizi Li, Yongjie Li, Fengxia Su, Yan Zhang, Zhuangyuan Tang, Jinghua Sun, Ya Gao, Xin Jin, Haiqiang Zhang   +9 more
doaj   +1 more source