Results 71 to 80 of about 5,021,226 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research on multi-robot scheduling algorithms based on machine vision

EURASIP Journal on Image and Video Processing, 2018
In the multi-robot system, how to achieve effective and reasonable task coordination between multi-robots is an important problem;, multi-robot task scheduling is the term used for the coordination of the key technologies.
Jing Li, Fan Yang
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Multi-Robot Cyber Physical System for Sensing Environmental Variables of Transmission Line

Sensors, 2018
The normal operation of a power grid largely depends on the effective monitoring and maintenance of transmission lines, which is a process that has many challenges.
Fei Fan, Gongping Wu, Man Wang, Qi Cao, Song Yang   +4 more
doaj   +1 more source

Novel Implementation of Multi-Robot Space Exploration Utilizing Coordinated Multi-Robot Exploration and Frequency Modified Whale Optimization Algorithm

IEEE Access, 2021
Multi-robot space exploration involves building a finite map utilizing a cluster of robots in an obstacle cluttered environment. The uncertainties are minimized by assigning tasks among robots and computing the optimum action.
Faiza Gul, Imran Mir, W. Rahiman, Tauqeer Ul Islam   +3 more
semanticscholar   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

SISTEM MULTI-ROBOT DENNGAN NXT MINDSTORMS ROBOT MENGGUNAKAN BLUETOOTH

Jurnal Ilmiah SINERGI, 2013
Teknologi dan aplikasi robot terus berkembang secara cepat. Pada dekade ini, telah terjadi pergeseran yang signifikan pada bidang fokus penyelidikan tentang robot dimana para peneliti mulai mengarahkan arah penelitiannya, dari investigasi sistem robot ...
Andi Adriansyah
doaj  

Towards Optimally Decentralized Multi-Robot Collision Avoidance via Deep Reinforcement Learning [PDF]

IEEE International Conference on Robotics and Automation, 2017
Developing a safe and efficient collision avoidance policy for multiple robots is challenging in the decentralized scenarios where each robot generates its paths without observing other robots' states and intents.
Pinxin Long, Tingxiang Fan, X. Liao, Wenxi Liu, H. Zhang, Jia Pan   +5 more
semanticscholar   +1 more source