Results 61 to 70 of about 5,119,496 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multi-robot heuristic goods transportation [PDF]

2012 6th IEEE INTERNATIONAL CONFERENCE INTELLIGENT SYSTEMS, 2012
In this paper, we consider the issue of transporting a certain number of goods by a team of mobile robots. The target is to minimize the total transportation time and keep a low energy consumption of the intelligent agents on assuring security and quality during the transportation process.
Zhi Yan 0001, Nicolas Jouandeau, Arab Ali Chérif   +2 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Research on multi-robot scheduling algorithms based on machine vision

EURASIP Journal on Image and Video Processing, 2018
In the multi-robot system, how to achieve effective and reasonable task coordination between multi-robots is an important problem;, multi-robot task scheduling is the term used for the coordination of the key technologies.
Jing Li, Fan Yang
doaj   +1 more source

A visibility information for multi-robot localization [PDF]

2013 IEEE/RSJ International Conference on Intelligent Robots and Systems, 2013
This paper proposes a set-membership method based on interval analysis to solve the pose tracking problem for a team of robots. The originality of this approach is to consider only weak sensor data: the visibility between two robots. The paper demonstrates that with this poor information, without using bearing or range sensors, a localization is ...
Guyonneau, Rémy, Lagrange, Sébastien, Hardouin, Laurent   +2 more
openaire   +3 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

On the consistency of multi-robot cooperative localization [PDF]

Robotics: Science and Systems V, 2009
In this paper, we investigate the consistency of extended Kalman filter (EKF)-based cooperative localization (CL) from the perspective of observability. To the best of our knowledge, this is the first work that analytically shows that the error-state system model employed in the standard EKF-based CL always has an observable subspace of higher ...
Guoquan P. Huang 0001, Nikolas Trawny, Anastasios I. Mourikis, Stergios I. Roumeliotis   +3 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source