Results 51 to 60 of about 85,877 (261)

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia

Infection and Drug Resistance, 2021
Ziad Amin,1 Habtamu Mitiku,2 Dadi Marami,2 Tadesse Shume,2 Fitsum Weldegebreal2 1Harari Health Research and Regional Laboratory, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health and Medical Science, Haramaya University ...
Amin Z, Mitiku H, Marami D, Shume T, Weldegebreal F   +4 more
doaj  

Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients

Brazilian Journal of Infectious Diseases, 2016
Background: Fluoroquinolones are the backbone of multidrug resistant tuberculosis treatment regimens. Despite the high burden of multidrug resistant tuberculosis in the country, little is known about drug resistance patterns, prevalence, and predictors ...
Nafees Ahmad, Arshad Javaid, Syed Azhar Syed Sulaiman, Long Chiau Ming, Izaz Ahmad, Amer Hayat Khan   +5 more
doaj   +1 more source

Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning

Macromolecular Rapid Communications, EarlyView.
Machine‐learning (ML) techniques using random forest classification models revealed key characteristics that predict effective antimicrobial peptides (AMPs) targeting Gram‐negative bacteria, Gram‐positive bacteria, and mycobacteria. The ideal cLogP (<$ < $−6) and net‐charge (≤+4) threshold was the same for all three targets with variations in the ...
Jooyoung Roh, Cyrille Boyer, Priyank V. Kumar   +2 more
wiley   +1 more source

Analysis of clinical and bronchoscopic features of multidrug-resistant tracheobronchial tuberculosis

BMC Infectious Diseases
Objective Investigate patients' clinical characteristics and bronchoscopic features with multidrug-resistant tracheobronchial tuberculosis. Methods A total of 118 patients with confirmed diagnosis of multidrug-resistant tracheobronchial tuberculosis were
Jian Li, Xue Li, Lulu Qiu, Guoyi Huang, Jiamin Huang, Zhichao Liu, Xue Ke, Xiufen Wang, Wenying Gao, Guobao Li   +9 more
doaj   +1 more source

Adverse effects profile of multidrug-resistant tuberculosis treatment in a South African outpatient clinic

South African Family Practice, 2012
Background: Highly active antiretroviral therapy (HAART) and drugs that are used to treat multidrug-resistant tuberculosis have potentially overlapping adverse effects.
T.Q. Jacobs, A. Ross
doaj   +1 more source

Drug-Resistant Tuberculosis—Current Dilemmas, Unanswered Questions, Challenges, and Priority Needs [PDF]

, 2017
Tuberculosis was declared a global emergency by the World Health Organization (WHO) in 1993. Following the declaration and the promotion in 1995 of directly observed treatment short course (DOTS), a cost-effective strategy to contain the tuberculosis ...
Abubakar, Ibrahim, Atun, Rifat, Chakaya, Jeremiah, Cox, Helen, Ditiu, Lucica, Ford, Nathan, Grobusch, Martin, Hoelscher, Michael, Lawn, Stephen D., Maeurer, Markus, Marais, Ben, Mchugh, Timothy D., McNerney, Ruth, Memish, Ziad, Migliori, Giovanni-Battista, Mwaba, Peter, O'Grady, Justin, Pletschette, Michel, Ramsay, Andrew, Raviglione, Mario, Schito, Marco, Squire, S. Bertel, Swaminathan, Soumya, Zumla, Alimuddin   +23 more
core  

Antibacterial Micro/Nanorobots: Innovations, Challenges, and Future Perspectives in Combatting Infection

Nano Select, EarlyView.
Antibacterial micro/nanorobots (MNRs) represent a breakthrough in antibacterial therapy, making precise delivery of drugs to the infection site. This review systematically summarizes the material composition, actuation, and applications of MNRs in combating biofilms and drug‐resistant infections while emphasizing the existing challenges of ...
Yichao Chen, Chenlin Jiang, Chuxie Zhang, Wenqing He, Changshun Hou   +4 more
wiley   +1 more source

Prevalence of and risk factors for multidrug-resistant tuberculosis in Iran and its neighboring countries: systematic review and meta-analysis

Revista da Sociedade Brasileira de Medicina Tropical
Tuberculosis, in particular drug-resistant tuberculosis, is of global concern due to the high mortality and morbidity associated with it annually. The aim of this study was to determine the prevalence of and the risk factors for multidrug-resistant ...
Worku Jimma, Marjan Ghazisaeedi, Leila Shahmoradi, Ahmed Abdulahi Abdurahman, Sharareh Rostam Niakan Kalhori, Mahshid Nasehi, Sharifi Yazdi, Reza Safdari   +7 more
doaj   +1 more source

Multidrug-resistant tuberculosis in children and response to therapy

Medical Journal of Dr. D.Y. Patil University, 2015
There is very little information available on drug-resistant (DR) tuberculosis (TB) in children in Indian scenario and especially their response to therapy. We present a series of children who were suffering from multidrug-resistant-TB and their response
Ira Shah
doaj   +1 more source