Results 61 to 70 of about 37,118 (221)

Optimal Control for Tuberculosis with Exogenous Reinfection and Stigmatization [PDF]

arXiv, 2021
The effect of stigmatization is hindering the control of diseases. Especially in the case of exogenous reinfection, this effect can play a massive role. We develop in this paper, based on a tuberculosis model of Feng et.al. a model with exogenous reinfection and stigmatization.
arxiv  

Establishing the Exposure‐QT Relationship During Bedaquiline Treatment Using a Time‐Varying Tuberculosis‐Specific Correction Factor (QTcTBT)

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evaluating QT prolongation induced by anti‐tuberculosis (TB) drugs in patients with active TB, who often experience tachycardia, is challenging due to the limitations of Fridericia's correction factor (QTcF) in decorrelating QTc from heart rate (HR).
Thanakorn Vongjarudech, Anne‐Gaëlle Dosne, Bart Remmerie, Mats O. Karlsson, Elin M. Svensson   +4 more
wiley   +1 more source

RESULTS OF CHEMOTHERAPY IN PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS IN THE REGIONS OF THE RUSSIAN FEDERATION

Туберкулез и болезни лёгких, 2014
The paper analyzes the results of treatment in 5,396 patients with multidrug-resistant tuberculosis who were treated in the regions of the Russian Federation under the Global Fund Round 4 project based on the recommended World Health Organization ...
V. V. Testov, S. A. Sterlikov, I. A. Vasilyeva, V. V. Erokhin, T. Ch. Kesaeva   +4 more
doaj  

Predictor factors for multidrug-resistant tuberculosis among patients with pulmonary tuberculosis in Huánuco, Peru. 2010-2015

Revista de la Facultad de Medicina Humana, 2020
Introduction: In the city of Huánuco and around the world, there is a progressive increase in cases of Tuberculosis and multidrug-resistant Tuberculosis, for this reason it was necessary to identify predictors to develop multidrug-resistant Tuberculosis.
Anghella Valdivia-Gómez , Noelia Zavala-Lazo, Bernardo Dámaso-Mata , Vicky Panduro-Correa, Edinho Segama-Fabian , Kovy Arteaga-Livias   +5 more
doaj   +1 more source

Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens

Small, EarlyView.
This review explores the potential of antimicrobial peptides (AMPs) and nanotechnology for the treatment of gastrointestinal infections. It analyzes bacterial resistance mechanisms, the antimicrobial actions of AMPs, and advances in nanocarriers, such as lipid‐based, polymeric, metallic, and mesoporous silica systems, that enhance peptide protection ...
Christian Shleider Carnero Canales, Cesar Augusto Roque‐Borda, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Uner Josseph Pinto Apaza, Vanderson de Jesus Silva, Laura Maria Duran Gleriani Primo, Maura Jennifer Martínez‐Morales, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +10 more
wiley   +1 more source

Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections

Small Science, EarlyView.
This review critically evaluates fluorescent antibiotics as promising agents combining diagnostic precision with therapeutic efficacy. It highlights advances in probe design, chemical conjugation strategies, real‐time imaging applications, selective pathogen detection, and targeted therapy. The potential to combat antimicrobial resistance is discussed,
Tan Phuoc Ton, Richard Bright, Vi Khanh Truong, Krasimir Vasilev   +3 more
wiley   +1 more source

Multidrug-resistant tuberculosis

BMC Infectious Diseases, 2008
Background With almost 9 million new cases each year, tuberculosis remains one of the most feared diseases on the planet. Led by the STOP-TB Partnership and WHO, recent efforts to combat the disease have made considerable progress in a number of ...
McNerney Ruth, Zager Ellen M
doaj   +1 more source

Relative bioavailability of delamanid 50 mg tablets dispersed in water in healthy adult volunteers

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 957-967, April 2025.
Aim Delamanid is a novel drug for the treatment of drug‐resistant tuberculosis, manufactured as 50‐mg solid and 25‐mg dispersible tablets. We evaluated the effects of dispersing the 50‐mg tablet, focusing on the relative bioavailability. Methods Delamanid, 50‐mg tablets administered dispersed vs swallowed whole, was investigated in a phase I, four ...
Yuanxi Zou, Veronique de Jager, Anneke C. Hesseling, Andreas H. Diacon, Lubbe Wiesner, Joni Mostert, Elin M. Svensson, Anthony Garcia‐Prats   +7 more
wiley   +1 more source

Factors associated with multidrug-resistant tuberculosis

IMC Journal of Medical Science, 2009
This case control study was conducted in selected centers of Dhaka City from March to July 2008 to determine the association of multidrug-resistant tuberculosis with the attributes related to treatment and socio-economic condition of tuberculosis ...
Md Nurul Amin, Md Anisur Rahman, Meerjady Sabrina Flora, Md Abul Kalam Azad   +3 more
doaj  

Antibiotic‐Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa

Immunology, EarlyView.
Antibiotic‐induced dysbiosis of the gut microbiota shifts host tryptophan metabolism and impairs the innate immune response during Pseudomonas aeruginosa pulmonary infection. (A) Eubiosis: During eubiosis, the intestinal microbiota metabolises tryptophan into indole metabolites, which keeps tryptophan levels within normal serum concentrations. However,
Camila Bernardo de Brito, Raquel Duque do Nascimento Arifa, Rafael de Oliveira Bezerra, Carlos Eduardo Dias Igídio, Bárbara Maria de Amorim‐Santos, Anna Clara Paiva de Menezes Santos, Larissa Mendes Barbosa, João Paulo Pezzini Barbosa, Larissa Marcely Gomes Cassiano, Markus Kohlhoff, Micheli Fagundes, Rafaela Ribeiro Álvares Batista, Celso Martins Queiroz‐Junior, Alessandra M. Saliba, Juliana Divina Almeida Raposo, Fernão Castro Braga, Roney Santos Coimbra, Mauro Martins Teixeira, Caio Tavares Fagundes, Danielle G. Souza   +19 more
wiley   +1 more source