Results 121 to 130 of about 262,601 (237)

Time‐Resolved Effects of Cold Atmospheric Plasma on E. coli GW‐AmxH19 Transcriptome and Proteome in an Emulated Wastewater Environment

PROTEOMICS, EarlyView.
ABSTRACT Cold atmospheric plasma (CAP) is effective against a variety of microorganisms. Here, we described effects on an Escherichia coli strain isolated from hospital wastewater caused by treatment with physical plasma. E. coli GW‐AmxH19 was incubated in artificial wastewater and treated for 15 min with CAP.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke, Susanne Sievers, Veronika Hahn, Mechthild Bömeke, Anja Poehlein, Dirk Albrecht, Juergen F. Kolb, Katharina Riedel, Rolf Daniel, Daniela Zühlke   +11 more
wiley   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Identification and characterisation of two functional antibiotic MATE efflux pumps in the archaeon Halorubrum amylolyticum

npj Antimicrobials and Resistance
Multidrug efflux pumps have been found to play a crucial role in drug resistance in bacteria and eukaryotes. In this study, we investigated the presence of functional multidrug and toxic compound extrusion (MATE) efflux pumps, inferred from whole genome ...
Asma A. Fakhoury, Thomas P. Thompson, Khondaker Miraz Rahman, Julianne Megaw, Matthew I. McAteer, Timofey Skvortsov, Stephen A. Kelly, Brendan F. Gilmore   +7 more
doaj   +1 more source

Investigating multidrug efflux pumps associated with fatty acid salt resistance in Escherichia coli. [PDF]

Front Microbiol, 2023
Yamasaki S, Yoneda T, Ikawa S, Hayashi-Nishino M, Nishino K.   +4 more
europepmc   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments. [PDF]

Appl Environ Microbiol, 2023
Subirats J, Sharpe H, Tai V, Fruci M, Topp E.   +4 more
europepmc   +1 more source

Cotton Farming Pesticides Affect Ileal Microbiota Activity and Expression of Virulome but Not Resistome or Metabolic Pathways in a Sedentary Wild Passerine

Environmental Toxicology, EarlyView.
ABSTRACT The increased use of agrochemicals to enhance crop production has had detrimental environmental effects including implication in the sharp decline of North American farmland‐breeding birds. Here, using a combination of deep shotgun metatranscriptomics and pesticide exposure data, we sought to assess whether exposure to cotton (Gossypium spp ...
Serguei V. Drovetski, Michelle L. Hladik, Carolina F. Ferreira, Dana W. Kolpin, Gary Voelker   +4 more
wiley   +1 more source

Identification of oxyresveratrol, a food-as-medicine substrate, as a novel EPI that targets the RND efflux pumps of Serratia surfactantfaciens sp. nov. YD25T

Microbiology Spectrum
Serratia marcescens is an opportunistic pathogen with increasing drug resistance. Serratia surfactantfaciens sp. nov. YD25T, a novel strain with multidrug resistance, shares similarities with S. marcescens.
Fuqiao Liu, Xiaoyu Wei, Yaoyu Lou, Yurong Wang, Danlu Zhang, Bing Cao, Chun Su, Yan Sun, Zhi Li   +8 more
doaj   +1 more source

Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance

, 2014
Gram-negative bacteria express a plethora of efflux pumps that are capable of transporting structurally varied molecules, including antibiotics, out of the bacterial cell.
Richmond, Grace E, Blair, Jessica M A; id_orcid, Piddock, Laura J V   +2 more
core   +1 more source