Results 241 to 250 of about 365,495 (322)

Widespread Skin Lesions in an Italian Man

JEADV Clinical Practice, EarlyView.
Rebecca Donadoni, Giulia Merlo, Gabriele Zanardi, Antonio Guadagno, Corrado Cabona, Stefania Artioli, Claudia Micalizzi, Emanuele Cozzani   +7 more
wiley   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential. [PDF]

PLoS One
Fang Z, Lin Z, Duan C, Liu X, Luo Z, Huang C, Li X, Zheng X.   +7 more
europepmc   +1 more source

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
wiley   +1 more source

Stromal COL11A1: Mechanisms of Stroma-Driven Multidrug Resistance in Breast Cancer and Biomarker Potential. [PDF]

Biomedicines
Onofrei Popa A, Mihailuta F, Mihalache D, Vodă CC, Jurja S, Deacu S, Mehedinți MC.   +6 more
europepmc   +1 more source

Green Synthesis of ZnO Nanoparticles From Spirulina platensis: Antimicrobial and Cytotoxic Evaluation With Molecular Docking Studies

ChemistryOpen, EarlyView.
Algal‐extract‐derived ZnO nanoparticles show shape anisotropy and are bio capped by phytochemicals. These green‐synthesized NPs strongly inhibit S. aureus and K. pneumoniae biofilms. Molecular docking suggests stable binding of surface biomolecules to microbial targets, highlighting synergistic antibacterial mechanisms.
Muhammad Rizwan, Izaz Khan, Syed Sikandar Shah, Amir hamza khan, Abdurahman Hajinur Hirad, Saira Naz, Arshad Farid, Taimoor Khan, Said Hassan   +8 more
wiley   +1 more source

Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function. [PDF]

J Pineal Res
López-Rodríguez A, Martinez-Ruiz L, Morales-Gallel R, Florido J, Bermejo-Casares F, Garcia-Verdugo JM, Estebané MM, Carriel V, Maldonado-Pérez N, González-García P, Ahmadpour ST, Ramírez-Casas Y, Martín F, Dumas JF, Vandier C, Yang Y, Acuña-Castroviejo D, Escames G.   +17 more
europepmc   +1 more source

A RationallyDesigned Sulfonium Lipoglycopeptide withMicelles Self-Assembly to Combat Multidrug Resistance via Dual EnhancedCell Wall-Membrane Inhibition and T7SS Proteins Downregulation

Yuanyuan Xie (662418), Xiaowen Wang (15759), Fang Li (41162), Zhifu Chen (10882254), Qun Li (222962), Shuhui Liu (495053), Jingwen Zhang (608423), Hui Wang (30400), Zhenyong Wu (19273915), Jinyong Zhang (199891), Dongliang Guan (4731594)   +10 more
openalex   +1 more source

Characterization of IS 6110 Restriction Fragment Length Polymorphism Patterns and Mechanisms of Antimicrobial Resistance for Multidrug-Resistant Isolates of Mycobacterium tuberculosis from a Major Reference Hospital in Assiut, Egypt

, 2001
Said Abbadi, Heba Rashed, Glenn P. Morlock, Charles L. Woodley, O. El Shanawy, Robert C. Cooksey   +5 more
openalex   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source