Results 31 to 40 of about 229,968 (250)

Models of multiple system atrophy [PDF]

Experimental & Molecular Medicine, 2019
AbstractMultiple system atrophy (MSA) is a neurodegenerative disease with diverse clinical manifestations, including parkinsonism, cerebellar syndrome, and autonomic failure. Pathologically, MSA is characterized by glial cytoplasmic inclusions in oligodendrocytes, which contain fibrillary forms of α-synuclein.
Lee, He-Jin, Ricarte, Diadem, Ortiz, Darlene, Lee, Seung-Jae   +3 more
openaire   +2 more sources

Multiple Sistem Atrophy: Sebuah Laporan Kasus

Aksona, 2021
Pendahuluan: Multiple sistem atrophy adalah penyakit degeneratif yang dapat menyebabkan kecacatan bahkan kematian. Sedikit jurnal yang yang membahas tentang diagnosis dan penanganan multiple system atrophy secara menyeluruh.
Edfina Rahmarini, Muhammad Hamdan, Priya Nugraha, Paulus Sugianto, Yudha Haryono   +4 more
doaj   +1 more source

Pan-American Consortium of Multiple System Atrophy (PANMSA). A Pan-American multicentre cohort study of Multiple System Atrophy

Journal of Parkinson’s Disease, 2014
Background: Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.
Emilia Gatto, Mayela Rodríguez-Violante, Carlos Cosentino, Pedro Chana-Cuevas, Marcelo Miranda, Ellin Gallin, Jose L. Etcheverry, Yesenia Nuñez, Virginia Parisi, Gabriel Persi, Celeste Vecchi, Ana Sanguinetti, Alejandro Alleva, Juliana Aparcana, Luis Torres, Irene Litvan   +15 more
doaj   +1 more source

Multiple system atrophy-cerebellar: A case report and literature review

Radiology Case Reports, 2023
We reported a case of a 48-year-old female patient admitted to the hospital due to balance disorder which progressed rapidly within 1 week. Cerebral magnetic resonance imaging showed significant atrophy and hyperintensities at the middle cerebellar ...
Thi Thuong Doan, MD, Thuy Dung Pham, MD, Duy Duan Nguyen, MD, Dac Hong An Ngo, MD, Trong Binh Le, MD, PhD, Thanh Thao Nguyen, MD, PhD   +5 more
doaj   +1 more source

Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

Radiology Case Reports, 2023
We encountered a case of multiple system atrophy parkinsonian subtype (MSA-P) with right-dominant parkinsonism in the early stage of the disease. Atrophy of the posterolateral putamen and iron deposition are the neuropathological hallmark of MSA-P ...
Koichiro Mori, MD, Akira Yagishita, MD, Toshio Shimizu, MD, PhD   +2 more
doaj   +1 more source

A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

Molecular Therapy: Nucleic Acids
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes.
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa   +13 more
doaj   +1 more source

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications

Neuroscience Research
Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD).
Norihito Uemura
doaj   +1 more source

External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis

Neural Regeneration Research, 2023
Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations.
Massimiliano Todisco, Giuseppe Cosentino, Enrico Alfonsi   +2 more
doaj   +1 more source

Diagnosis of multiple system atrophy [PDF]

Autonomic Neuroscience, 2018
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease.
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source