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Multiple system atrophy [PDF]

, 2019
Multiple system atrophy (MSA) is a sporadic, adult-onset, relentlessly progressive neurodegenerative disorder, clinically characterized by various combinations of autonomic failure, parkinsonism and ataxia. The neuropathological hallmark of MSA are glial cytoplasmic inclusions consisting of misfolded α-synuclein.
Fanciulli, Alessandra, Stankovic, Iva, Krismer, Florian, Seppi, Klaus, Levin, Johannes, Wenning, Gregor K.   +5 more
openaire   +4 more sources

Freezing of Gait in Multiple System Atrophy

Frontiers in Aging Neuroscience, 2022
Background and PurposeFreezing of gait (FOG) is a common gait disturbance phenomenon in multiple system atrophy (MSA) patients. The current investigation assessed the incidence FOG in a cross-sectional clinical study, and clinical correlations associated
Huaguang Yang, Weiyin Vivian Liu, Shanshan Wang, Wenbin Yang, Changsheng Liu, Zhi Wen, Lanhua Hu, Jinxia Guo, Guoguang Fan, Xiaoguang Luo, Yunfei Zha   +10 more
doaj   +1 more source

Multiple system atrophy - a clinicopathological update

Free Neuropathology, 2020
Multiple system atrophy (MSA) is a fatal, adult-onset neurodegenerative disorder of uncertain etiology, clinically characterized by various combinations of Levo-dopa-unresponsive parkinsonism, and cerebellar, motor, and autonomic dysfunctions.
Kurt A. Jellinger
doaj   +1 more source

Heterogeneity of Multiple System Atrophy: An Update

Biomedicines, 2022
Multiple system atrophy (MSA) is a fatal, rapidly progressing neurodegenerative disease of uncertain etiology, clinically characterized by various combinations of Levodopa unresponsive parkinsonism, cerebellar, autonomic and motor dysfunctions.
Kurt A. Jellinger
doaj   +1 more source

The genetic basis of multiple system atrophy

Journal of Translational Medicine, 2023
Multiple system atrophy (MSA) is a heterogenous, uniformly fatal neurodegenerative ɑ-synucleinopathy. Patients present with varying degrees of dysautonomia, parkinsonism, cerebellar dysfunction, and corticospinal degeneration.
Fan Shuen Tseng, Joel Qi Xuan Foo, Aaron Shengting Mai, Eng-King Tan   +3 more
doaj   +1 more source

Multiple Sistem Atrophy: Sebuah Laporan Kasus

Aksona, 2021
Pendahuluan: Multiple sistem atrophy adalah penyakit degeneratif yang dapat menyebabkan kecacatan bahkan kematian. Sedikit jurnal yang yang membahas tentang diagnosis dan penanganan multiple system atrophy secara menyeluruh.
Edfina Rahmarini, Muhammad Hamdan, Priya Nugraha, Paulus Sugianto, Yudha Haryono   +4 more
doaj   +1 more source

Multiple system atrophy-cerebellar: A case report and literature review

Radiology Case Reports, 2023
We reported a case of a 48-year-old female patient admitted to the hospital due to balance disorder which progressed rapidly within 1 week. Cerebral magnetic resonance imaging showed significant atrophy and hyperintensities at the middle cerebellar ...
Thi Thuong Doan, MD, Thuy Dung Pham, MD, Duy Duan Nguyen, MD, Dac Hong An Ngo, MD, Trong Binh Le, MD, PhD, Thanh Thao Nguyen, MD, PhD   +5 more
doaj   +1 more source

Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

Radiology Case Reports, 2023
We encountered a case of multiple system atrophy parkinsonian subtype (MSA-P) with right-dominant parkinsonism in the early stage of the disease. Atrophy of the posterolateral putamen and iron deposition are the neuropathological hallmark of MSA-P ...
Koichiro Mori, MD, Akira Yagishita, MD, Toshio Shimizu, MD, PhD   +2 more
doaj   +1 more source

Pan-American Consortium of Multiple System Atrophy (PANMSA). A Pan-American multicentre cohort study of Multiple System Atrophy

Journal of Parkinson’s Disease, 2014
Background: Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.
Emilia Gatto, Mayela Rodríguez-Violante, Carlos Cosentino, Pedro Chana-Cuevas, Marcelo Miranda, Ellin Gallin, Jose L. Etcheverry, Yesenia Nuñez, Virginia Parisi, Gabriel Persi, Celeste Vecchi, Ana Sanguinetti, Alejandro Alleva, Juliana Aparcana, Luis Torres, Irene Litvan   +15 more
doaj   +1 more source

External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis

Neural Regeneration Research, 2023
Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations.
Massimiliano Todisco, Giuseppe Cosentino, Enrico Alfonsi   +2 more
doaj   +1 more source