Results 171 to 180 of about 5,957 (192)

Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors

Experimental Eye Research, 2009
Musashi-1 (Msi1), an RNA-binding protein (RBP), has been postulated to play important roles in the maintenance of the stem-cell state, differentiation, and tumorigenesis. However, the expression and function of Msi1 in differentiated cells remain obscure.
Kanako, Susaki, Jun, Kaneko, Yuka, Yamano, Kenta, Nakamura, Wataru, Inami, Taro, Yoshikawa, Yoko, Ozawa, Shinsuke, Shibata, Osamu, Matsuzaki, Hideyuki, Okano, Chikafumi, Chiba   +10 more
openaire   +2 more sources

Abstract 4817: Molecular cancer therapy targeting RNA-binding protein Musashi-1

Cancer Research, 2016
Abstract Musashi-1 (MSI1) is an evolutionarily conserved RNA-binding protein best studied for its role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancers including colon cancer are associated with up-regulation of Notch/Wnt signaling.
Lan Lan, Hao Liu, Amber Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca Marquez, Xiaoqing Wu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto De Guzman, Steven Rogers, Jeffrey Aubé, Kristi Neufeld, Liang Xu   +15 more
openaire   +1 more source

Expression of a putative stem cell marker, Musashi 1, in mammary glands of ewes

Journal of Molecular Histology, 2009
Several recent studies demonstrated that development, function and remodelling of mammary glands involved multipotent cells, but no specific molecular markers for mammary epithelial stem cells were revealed. These studies principally concerned human and mouse mammary tissue, but mammary stem cells could be a valuable tool in agricultural production and
COLITTI, Monica, FARINACCI M.
openaire   +3 more sources

Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells

Journal of Gastroenterology, 2009
Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs.A human intestinal epithelial cell line ...
Minekazu, Murayama, Ryuichi, Okamoto, Kiichiro, Tsuchiya, Junko, Akiyama, Tetsuya, Nakamura, Naoya, Sakamoto, Takanori, Kanai, Mamoru, Watanabe   +7 more
openaire   +2 more sources

Characterization of Musashi-1 in Pediatric Group 3 Medulloblastoma

2020
Brain tumours are the leading cause of childhood cancer death with medulloblastoma (MB) representing the most frequent malignant childhood brain tumour. Analysis of the data retrieved from multiple genetic studies of MB, we have determined that there are 4 genetic subgroups of MB: Wnt, Shh, Group 3 (G3) and Group 4 (G4).
openaire   +1 more source

[Musashi-1 positively regulates growth and proliferation of hepatoma cells in vitro].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020
To investigate the regulatory role of Musashi-1 (MSI1) in the proliferation and growth of hepatocellular carcinoma (HCC) cells.We examined the expression of MSI1 in HCC and paired adjacent tissues from 24 patients using immunohistochemistry and Western blotting. A MSI1-expressing vector was constructed and stably transfected into HepG2 cells, and short
Jie, Li, Kun, Yan, Yi, Yang, Hua, Li, Zhidong, Wang, Xin, Xu   +5 more
openaire   +1 more source

Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT

OncoTargets and Therapy, 2021
Weiwei Sheng, Ming Dong
exaly  

The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice

Journal of Biological Chemistry, 2021
Fatimah Matalkah, Bohye Jeong, Peter Stoilov   +2 more
exaly  

Gene Musashi-1 em meduloblastoma de grupo 3 e 4

2022
openaire   +1 more source

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

Nature, 2016
Stefan Rentas, Gabriel Pratt, Veronique Voisin   +2 more
exaly