Results 61 to 70 of about 124,416 (341)

Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor*

Journal of Biological Chemistry, 2014
Background: Bitopic ligands bind concomitantly to orthosteric and allosteric receptor sites. Results: Residues affecting binding and biased signaling of the selective agonists TBPB and 77-LH-28-1 were identified at the M1 muscarinic receptor. Conclusion:
Peter Keov, Laura Lopez, Shane M. Devine, C. Valant, J. R. Lane, P. Scammells, P. Sexton, A. Christopoulos   +7 more
semanticscholar   +1 more source

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, EarlyView.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Acetylcholine Attenuates Hydrogen Peroxide-Induced Intracellular Calcium Dyshomeostasis Through Both Muscarinic and Nicotinic Receptors in Cardiomyocytes

Cellular Physiology and Biochemistry, 2016
Background/Aims: Oxidative stress induced intracellular Ca2+ overload plays an important role in the pathophysiology of several heart diseases. Acetylcholine (ACh) has been shown to suppress reactive oxygen species generation during oxidative stress ...
Siripong Palee, Nattayaporn Apaijai, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn   +4 more
doaj   +1 more source

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor*

Journal of Biological Chemistry, 2014
Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity.
Alaa Abdul-Ridha, J. R. Lane, Shailesh N Mistry, Laura Lopez, P. Sexton, P. Scammells, A. Christopoulos, Meritxell Canals   +7 more
semanticscholar   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]

, 2001
DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof, Frohman, Michael A, Zhao, Di   +2 more
core   +3 more sources

Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

Frontiers in Cardiovascular Medicine, 2022
Atrial fibrillation (AF), one of the most common arrhythmias, is associated with chronic emotional disorder. Chronic pain represents a psychological instability condition related to cardiovascular diseases, but the mechanistic linkage connecting chronic ...
Chao Gong, Yu Ding, Feng Liang, Shuang Wu, Xiruo Tang, Hongzhang Ding, Wenjing Huang, Xiaotong Yu, Likun Zhou, Jun Li, Shaowen Liu   +10 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]

, 2015
The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo, Bassi, Sabrina Cecilia, Seney, Marianne L., Sibille, Etienne   +3 more
core   +1 more source

Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor

Nature, 2012
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (
A. Kruse, Jianxin Hu, Albert C. Pan, Daniel H Arlow, D. Rosenbaum, Erica Rosemond, Hillary F. Green, Tong Liu, P. S. Chae, R. Dror, D. Shaw, W. Weis, J. Wess, B. Kobilka   +13 more
semanticscholar   +1 more source