Results 1 to 10 of about 34,340 (262)

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

Genes, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Acevedo, Antje Banning, Boman, Bonner, Caulfield, Caumont, Cheng, Claing, Coso, Crespo, Dascher, Delaney, Elorza, Ferguson, Fisher, Franco, Frucht, Grando, Grando, Hawes, Hawes, He, Hein, Hulme, Jin, Jones, Jones, Lee, Lee, Leiros, Lenhard, McCole, Michal, Miyakawa, Nguyen, Pals-Rylaarsdam, Pals-Rylaarsdam, Pitcher, Prenzel, Reiner, Ritva Tikkanen, Roseberry, Rosenblum, Shah, Simone Bocksberger, Sina Kühne, Taylor, Tohgo, Tsuga, van Biesen, van Koppen, Vogler, Vogler, Wang, Wickman, Williams, Wu, Wymke Ockenga, Zhang   +58 more
core   +9 more sources

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes [PDF]

Science, 2019
Choosing a partner G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs.
S. Maeda, Q. Qu, M. Robertson, G. Skiniotis, B. Kobilka   +4 more
semanticscholar   +5 more sources

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity [PDF]

Scientific Reports, 2017
Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
I-Shan Chen, Kazuharu Furutani, Yoshihisa Kurachi   +2 more
doaj   +2 more sources

Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor [PDF]

Membranes, 2015
The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj   +3 more sources

Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes [PDF]

Journal of Biological Chemistry, 1998
Internalization and down-regulation of human muscarinic acetylcholine m2 receptors (hm2 receptors) and a hm2 receptor mutant lacking a central part of the third intracellular loop (I3-del m2 receptor) were examined in Chinese hamster ovary (CHO-K1) cells
H. Tsuga, K. Kameyama, T. Haga, T. Honma, J. Lameh, W. Sadee   +5 more
semanticscholar   +2 more sources

M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation [PDF]

World Allergy Organization Journal, 2013
Airways chronic inflammatory conditions in asthma and COPD are characterized by tissue remodeling, being smooth muscle hyperplasia, the most important feature.
Fabiola A. Placeres-Uray, Christopher A. Febres-Aldana, Ruth Fernandez-Ruiz, Ramona Gonzalez de Alfonzo, Itala A. Lippo de Becemberg, Marcelo J. Alfonzo   +5 more
doaj   +3 more sources

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. [PDF]

Proceedings of the National Academy of Sciences, 1999
Members of the muscarinic acetylcholine receptor family (M1–M5) are known to be involved in a great number of important central and peripheral physiological and pathophysiological processes. Because of the overlapping expression patterns of the M1–M5 muscarinic receptor subtypes and the lack of ligands endowed with sufficient subtype selectivity ...
J. Gomeza, H. Shannon, E. Kostenis, C. Felder, Lu Zhang, J. Brodkin, A. Grinberg, Hui Sheng, J. Wess   +8 more
semanticscholar   +3 more sources

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist [PDF]

Nature, 2011
The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves.
K. Haga, A. Kruse, H. Asada, Takami Yurugi-Kobayashi, M. Shiroishi, Cheng Zhang, W. Weis, T. Okada, B. Kobilka, T. Haga, Takuya Kobayashi   +10 more
semanticscholar   +3 more sources

On homology modeling of the M2 muscarinic acetylcholine receptor subtype [PDF]

Journal of Computer-Aided Molecular Design, 2013
Twelve homology models of the human M2 muscarinic receptor using different sets of templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON).
J. Jakubík, Alena Randáková, V. Doležal   +2 more
semanticscholar   +2 more sources

Modulation of the M2 Muscarinic Acetylcholine Receptor Activity with Monoclonal Anti-M2 Receptor Antibody Fragments* [PDF]

Journal of Biological Chemistry, 2004
Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single
J. Peter, G. Wallukat, J. Tugler, D. Maurice, J. Roegel, J. Briand, J. Hoebeke   +6 more
semanticscholar   +3 more sources