Results 1 to 10 of about 8,042 (135)

Dualsteric Agonist for M2 Muscarinic Receptor Causes Oxidative Stress and Mitochondrial Alteration in Human Glioblastoma Cancer Stem Cells. [PDF]

J Neurochem
Dualsteric agonist N8‐iper shows cytotoxic effects on glioblastoma cancer stem cells, but not on human normal astrocytes. Lipid accumulation appears as a consequence of cytotoxic stress; in fact, they are not present in healthy astrocytes. ABSTRACT Glioblastoma (GB) is the most malignant form of human brain tumor, characterized by heterogeneous cell ...
Guerriero C, De Nuccio C, Petrone M, Rinaldi T, Cirigliano A, Visentin S, Bernardo A, Conti L, Matera C, De Amici M, Dallanoce C, Tata AM.   +11 more
europepmc   +2 more sources

The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in Saccharomyces cerevisiae [PDF]

Microbial Cell
Glioblastoma is a malignant astrocytic tumor of the brain. A significantly decrease of glioblastoma cell proliferation and survival can be achieved by activating the M2 muscarinic acetylcholine receptor (a G protein-coupled receptor, or GPCR) with two ...
Angela Cirigliano, Antonia Amelina, Elena Passarini, Alessandra Ricelli, Nicole Balasco, Mattia Mori, Bruno Botta, Maria Egle De Stefano, Claudio Papotto, Claudia Guerriero, Ada Maria Tata, Teresa Rinaldi   +11 more
doaj   +2 more sources

Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities [PDF]

Communications Biology
Medullary serotonergic (5-HT) neurons play a pivotal role in locomotor initiation. While these neurons receive cholinergic innervation, the functional consequences and underlying mechanisms remain poorly understood. Using ePet-EYFP transgenic mice (P3–P6)
Yi Cheng, Yue Dai, Renkai Ge, Qiang Zhang   +3 more
doaj   +2 more sources

Gomisin E attenuates pentobarbital-induced sleep deficits in aging-related insomnia: an in vivo and in silico study implicating cholinergic signaling [PDF]

Frontiers in Psychology
ObjectiveTo investigate the therapeutic effects of gomisin E on insomnia in aged rats and to elucidate the underlying mechanisms.MethodsAn aging-related insomnia rat model was established by intraperitoneal injection of D-galactose combined with p ...
Fan Yang, Fen Jiang, Fen Jiang, Xuewei Li   +3 more
doaj   +2 more sources

Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

Frontiers in Cardiovascular Medicine, 2022
Atrial fibrillation (AF), one of the most common arrhythmias, is associated with chronic emotional disorder. Chronic pain represents a psychological instability condition related to cardiovascular diseases, but the mechanistic linkage connecting chronic ...
Chao Gong, Yu Ding, Feng Liang, Shuang Wu, Xiruo Tang, Hongzhang Ding, Wenjing Huang, Xiaotong Yu, Likun Zhou, Jun Li, Shaowen Liu   +10 more
doaj   +1 more source

Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Molecular Brain, 2022
Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant
Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean, Kazutaka Ikeda   +6 more
doaj   +1 more source

General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain

Frontiers in Physiology, 2023
General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos, Dariia O. Dryn, Mariia I. Melnyk, Mariia I. Melnyk   +3 more
doaj   +1 more source

Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)

Communications Biology, 2021
Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C ...
Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori   +8 more
doaj   +1 more source

Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts

Journal of Pharmacological Sciences, 2009
.: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga, Takahisa Murata, Muneyoshi Okada, Masatoshi Hori, Hiroshi Ozaki   +4 more
doaj   +1 more source

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. [PDF]

PLoS ONE, 2015
The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity
Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klein   +3 more
doaj   +1 more source