Results 1 to 10 of about 16,257 (226)

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity [PDF]

Scientific Reports, 2017
Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
I-Shan Chen, Kazuharu Furutani, Yoshihisa Kurachi   +2 more
doaj   +2 more sources

Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R) [PDF]

Communications Biology, 2021
Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C ...
Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori   +8 more
doaj   +2 more sources

Notch Signal Mediates the Cross-Interaction between M2 Muscarinic Acetylcholine Receptor and Neuregulin/ErbB Pathway: Effects on Schwann Cell Proliferation [PDF]

Biomolecules, 2022
The cross-talk between axon and glial cells during development and in adulthood is mediated by several molecules. Among them are neurotransmitters and their receptors, which are involved in the control of myelinating and non-myelinating glial cell ...
Roberta Piovesana, Annalinda Pisano, Simona Loreti, Ruggero Ricordy, Claudio Talora, Ada Maria Tata   +5 more
doaj   +2 more sources

M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation

World Allergy Organization Journal, 2013
Airways chronic inflammatory conditions in asthma and COPD are characterized by tissue remodeling, being smooth muscle hyperplasia, the most important feature.
Fabiola A. Placeres-Uray, Christopher A. Febres-Aldana, Ruth Fernandez-Ruiz, Ramona Gonzalez de Alfonzo, Itala A. Lippo de Becemberg, Marcelo J. Alfonzo   +5 more
doaj   +2 more sources

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats [PDF]

Scientific Reports, 2017
The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells.
Marzia Soligo, Sonia Piccinin, Virginia Protto, Francesca Gelfo, Maria Egle De Stefano, Fulvio Florenzano, Erica Berretta, Laura Petrosini, Robert Nisticò, Luigi Manni   +9 more
doaj   +3 more sources

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Acevedo, Antje Banning, Boman, Bonner, Caulfield, Caumont, Cheng, Claing, Coso, Crespo, Dascher, Delaney, Elorza, Ferguson, Fisher, Franco, Frucht, Grando, Grando, Hawes, Hawes, He, Hein, Hulme, Jin, Jones, Jones, Lee, Lee, Leiros, Lenhard, McCole, Michal, Miyakawa, Nguyen, Pals-Rylaarsdam, Pals-Rylaarsdam, Pitcher, Prenzel, Reiner, Ritva Tikkanen, Roseberry, Rosenblum, Shah, Simone Bocksberger, Sina Kühne, Taylor, Tohgo, Tsuga, van Biesen, van Koppen, Vogler, Vogler, Wang, Wickman, Williams, Wu, Wymke Ockenga, Zhang   +58 more
core   +5 more sources

Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

Frontiers in Cardiovascular Medicine, 2022
Atrial fibrillation (AF), one of the most common arrhythmias, is associated with chronic emotional disorder. Chronic pain represents a psychological instability condition related to cardiovascular diseases, but the mechanistic linkage connecting chronic ...
Chao Gong, Yu Ding, Feng Liang, Shuang Wu, Xiruo Tang, Hongzhang Ding, Wenjing Huang, Xiaotong Yu, Likun Zhou, Jun Li, Shaowen Liu   +10 more
doaj   +1 more source

Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Molecular Brain, 2022
Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant
Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean, Kazutaka Ikeda   +6 more
doaj   +1 more source

General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain

Frontiers in Physiology, 2023
General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos, Dariia O. Dryn, Mariia I. Melnyk, Mariia I. Melnyk   +3 more
doaj   +1 more source

Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium [PDF]

, 1995
In the human isolated myocardium, acetylcholine (10−9 to 10−3 M) elicited a biphasic inotropic effect (a decrease in the lower and an increase in the higher concentration range) in atrial and a positive inotropic effect in ventricular trabeculae. However,
Bos, E. (Egbert), Du, X.Y. (Xiaoyi), Saxena, P.R. (Pramod Ranjan), Schoemaker, R.G. (Regien)   +3 more
core   +7 more sources