Results 1 to 10 of about 25,929 (155)

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes [PDF]

Science, 2019
Choosing a partner G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs.
S. Maeda, Q. Qu, M. Robertson, G. Skiniotis, B. Kobilka   +4 more
semanticscholar   +3 more sources

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

Genes, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Wymke Ockenga, S. Kühne, S. Bocksberger, A. Banning, R. Tikkanen   +4 more
semanticscholar   +5 more sources

Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes [PDF]

Journal of Biological Chemistry, 1998
Internalization and down-regulation of human muscarinic acetylcholine m2 receptors (hm2 receptors) and a hm2 receptor mutant lacking a central part of the third intracellular loop (I3-del m2 receptor) were examined in Chinese hamster ovary (CHO-K1) cells
H. Tsuga, K. Kameyama, T. Haga, T. Honma, J. Lameh, W. Sadee   +5 more
semanticscholar   +2 more sources

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. [PDF]

Proceedings of the National Academy of Sciences, 1999
Members of the muscarinic acetylcholine receptor family (M1–M5) are known to be involved in a great number of important central and peripheral physiological and pathophysiological processes. Because of the overlapping expression patterns of the M1–M5 muscarinic receptor subtypes and the lack of ligands endowed with sufficient subtype selectivity ...
J. Gomeza, H. Shannon, E. Kostenis, C. Felder, Lu Zhang, J. Brodkin, A. Grinberg, Hui Sheng, J. Wess   +8 more
semanticscholar   +3 more sources

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist [PDF]

Nature, 2011
The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves.
K. Haga, A. Kruse, H. Asada, Takami Yurugi-Kobayashi, M. Shiroishi, Cheng Zhang, W. Weis, T. Okada, B. Kobilka, T. Haga, Takuya Kobayashi   +10 more
semanticscholar   +3 more sources

Modulation of the M2 Muscarinic Acetylcholine Receptor Activity with Monoclonal Anti-M2 Receptor Antibody Fragments* [PDF]

Journal of Biological Chemistry, 2004
Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single
J. Peter, G. Wallukat, J. Tugler, D. Maurice, J. Roegel, J. Briand, J. Hoebeke   +6 more
semanticscholar   +3 more sources

On homology modeling of the M2 muscarinic acetylcholine receptor subtype [PDF]

Journal of Computer-Aided Molecular Design, 2013
Twelve homology models of the human M2 muscarinic receptor using different sets of templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON).
J. Jakubík, Alena Randáková, V. Doležal   +2 more
semanticscholar   +2 more sources

Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli. [PDF]

Journal of Biochemistry, 2000
The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP) at its N-terminus and expressed in Escherichia coli. The expression level was 0.2 nmol receptor per
Hiro Furukawa, T. Haga
semanticscholar   +3 more sources

Multiple Topological Domains Mediate Subtype-specific Internalization of the M2 Muscarinic Acetylcholine Receptor* [PDF]

Journal of Biological Chemistry, 2000
Endocytosis of agonist-activated G protein-coupled receptors (GPCRs) is required for both resensitization and recycling to the cell surface as well as lysosomal degradation.
Michael L. Schlador, R. Grubbs, N. Nathanson   +2 more
semanticscholar   +3 more sources

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
R. Pals‐Rylaarsdam, V. Gurevich, Katharine B. Lee, J. Ptasienski, J. Benovic, M. Hosey   +5 more
semanticscholar   +2 more sources