Results 161 to 170 of about 30,424 (296)

Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

Human Molecular Genetics, 2009
S. Cohen-Woods, D. Gaysina, N. Craddock, A. Farmer, J. Gray, C. Gunasinghe, F. Hoda, L. Jones, J. Knight, A. Korszun, M. Owen, A. Sterne, I. Craig, P. McGuffin   +13 more
semanticscholar   +1 more source

Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways.

The Journal of biological chemistry, 1997
Recent studies have identified agonist-dependent phosphorylation as a critical event in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and sequestration of the receptors away from the cell surface. However, mutant m2 mAChRs were identified that were phosphorylated but unable to desensitize in adenylyl cyclase ...
R, Pals-Rylaarsdam, V V, Gurevich, K B, Lee, J A, Ptasienski, J L, Benovic, M M, Hosey   +5 more
openaire   +1 more source

Inhaled glycopyrrolate for the treatment of chronic obstructive pulmonary disease

International Journal of COPD, 2018
Donald P Tashkin,1 Nicholas J Gross2 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, University Medical Research LLC, Saint Francis Hospital and Medical Center, Hartford, CT, USA Abstract:
Tashkin DP, Gross NJ
doaj  

Dynamic Targeting of the Agonist-stimulated m2 Muscarinic Acetylcholine Receptor to Caveolae in Cardiac Myocytes [PDF]

, 1997
Olivier Féron, Thomas W. Smith, Thomas Michel, Ralph A. Kelly   +3 more
openalex   +1 more source

Utility of an “Allosteric Site-Impaired” M2 Muscarinic Acetylcholine Receptor as a Novel Construct for Validating Mechanisms of Action of Synthetic and Putative Endogenous Allosteric Modulators [PDF]

, 2018
Ee Von Moo, Patrick M. Sexton, Arthur Christopoulos, Céline Valant   +3 more
openalex   +1 more source

The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins

, 2008
Cindy Reiner, Neil M. Nathanson
openalex   +1 more source

Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction. [PDF]

Cell Commun Signal
Polishchuk A, Just-Borràs L, Cilleros-Mañé V, Balanyà-Segura M, Silvera Simón C, Tomàs M, Jami El Hirchi M, Díaz-Wallach M, Hurtado E, Tomàs J, Lanuza MA.   +10 more
europepmc   +1 more source

Coupling of muscarinic acetylcholine receptors, m1/m3 and m2/m4, to phosphoinositide metabolism and Ca2+ channels in DNA-transfected NG108-15 cells.

, 1991
Haruhiro Higashida, Mami Noda, Yasuhiro Kimura, Minako HASHII   +3 more
openalex   +2 more sources

Negative Allosteric Modulation of Agonist-Induced M₂ Muscarinic Receptor/β-Arrestin Interaction by Serum Autoantibodies from Patients with Chronic Chagas Disease. [PDF]

Cells
Carrera Páez LC, Beltrame SP, Auger SR, Sabra AH, Bilder CR, Irurzun IM, Waldner CI, Goin JC.   +7 more
europepmc   +1 more source

Faculty Opinions recommendation of Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.

, 2018
Robert A. Copeland
openalex   +2 more sources