Results 31 to 40 of about 11,132 (239)
Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]
Genes, 2013 Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven transmembrane helix receptors.
Ockenga, Wymke +5 more
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Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
Molecular Brain, 2022 Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant
Masayo Fujita +6 more
doaj +1 more source
Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]
Journal of Biological Chemistry, 1997 Recent studies have identified agonist-dependent phosphorylation as a critical event in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and sequestration of the receptors away from the cell surface. However, mutant m2 mAChRs were identified that were phosphorylated but unable to desensitize in adenylyl cyclase ...
Katharine B. Lee +5 more
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Frontiers in Physiology, 2023 General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to ...
Alexander V. Zholos +3 more
doaj +1 more source
Communications Biology, 2021 Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C ...
Kota Katayama +8 more
doaj +1 more source
On homology modeling of the M2 muscarinic acetylcholine receptor subtype [PDF]
Journal of Computer-Aided Molecular Design, 2013 Twelve homology models of the human M(2) muscarinic receptor using different sets of templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON). The best models were obtained using single template of the closest published structure, the M(3) muscarinic receptor (PDB:4DAJ).
Jan Jakubík +2 more
openaire +2 more sources
Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. [PDF]
PLoS ONE, 2015 The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity
Franziska Mohr +3 more
doaj +1 more source
Frontiers in Neural Circuits, 2021 Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan +2 more
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Position of anticholinergic drugs in the treatment of childhood asthma [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2010 Anticholinergic drugs block muscarinic effect of acetylcholine on the receptors of postjunctional membranes and so inhibit the answer of the postganglionic parasympathetic nerve.
Stojković-Anđelković Anđelka +3 more
doaj +1 more source
Cells, 2022 Irritable bowel syndrome (IBS) is a chronic functional bowel disorder characterized by intestinal dysmotility. Changes in intestinal microbiota (dysbiosis) can lead to alterations in neuro-muscular functions in the gut. Toll-like receptors (TLRs) 2 and 4
Elena Layunta +2 more
doaj +1 more source