Results 41 to 50 of about 7,912 (220)

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

Digital Chinese Medicine, 2018
: Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by ...
Wei-Jie Qiang, Ying Chen, Fu-Yuan He, Mei-Feng Xiao, Wei-Yan Cai, Yi-Fei Dai, Qing Yang, Yu-Jie Li, Xiao-Gang Weng, Qi Li, Ya-Jie Wang, Xiao-Xin Zhu   +11 more
doaj   +1 more source

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

M2-AChR Mediates Rapid Antidepressant Effects of Scopolamine Through Activating the mTORC1-BDNF Signaling Pathway in the Medial Prefrontal Cortex

Frontiers in Psychiatry, 2021
Background: Scopolamine, a non-selective muscarinic acetylcholine receptor (M1~5-AChR) antagonist, has rapid and robust antidepressant effects in humans and other species. However, which of the five M-AChRs mediates these therapeutic effects has not been
Shuang Liu, Dandan Shi, Zuoli Sun, Yi He, Jian Yang, Jian Yang, Gang Wang, Gang Wang   +7 more
doaj   +1 more source

Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs. [PDF]

PLoS ONE, 2013
Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products ...
Kirsten C Verhein, Francesco G Salituro, Mark W Ledeboer, Allison D Fryer, David B Jacoby   +4 more
doaj   +1 more source

β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints. [PDF]

PLoS ONE, 2016
Acupuncture at homotopic acupoints or heterotopic acupoints is known to either inhibit or facilitate gastrointestinal motility, depending on the acupoint location.
Xinyan Gao, Yuxue Zhao, Yangshuai Su, Kun Liu, Xiaochun Yu, Changxiang Cui, Zhaokun Yang, Hong Shi, Xianghong Jing, Bing Zhu   +9 more
doaj   +1 more source

Drug Repurposing on G Protein-Coupled Receptors Using a Computational Profiling Approach

Frontiers in Molecular Biosciences, 2021
G protein-coupled receptors (GPCRs) are the largest human membrane receptor family regulating a wide range of cell signaling. For this reason, GPCRs are highly desirable drug targets, with approximately 40% of prescribed medicines targeting a member of ...
Alessandra de Felice, Simone Aureli, Vittorio Limongelli, Vittorio Limongelli   +3 more
doaj   +1 more source

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

Oral Vitamin C Intake Ameliorates Crude Oil-Polluted Water-Induced Jejunal Contractile Dysfunctions in Wistar rats

Journal of Applied Sciences and Environmental Management, 2023
Inhabitants of rural Niger-Delta oil communities in Nigeria often, unintentionally, consume crude oil polluted water (COCW) due to crude oil spills in the region. The impact of vitamin C supplementation during COCW ingestion on the contractile mechanism
S. A. Salami, A. J. Oyemakinde, M. O. Allen, H. M. Salahdeen, I. I. Olatunji-Bello, B. A. Murtala   +5 more
doaj   +1 more source

Pushing Biomolecule Detection Limit With Graphene Field‐effect Transistor Biosensors

Advanced Electronic Materials, EarlyView.
Graphene knows your health! This work presents a comprehensive overview of recent advances in graphene field‐effect transistor (GFET) biosensors for ultrasensitive biomolecule detection. How device engineering, high‐mobility graphene synthesis, and tailored surface chemistry push detection limits is highlighted, while discussing emerging strategies ...
Co Dang Pham, Quang Thang Trinh, Jun Zhang, Nam‐Trung Nguyen, Tuan‐Khoa Nguyen   +4 more
wiley   +1 more source

Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice

Neurobiology of Disease, 2006
In 7-month-old TgCRND8 mice, the extracellular cortical acetylcholine levels in vivo, the number and morphology of cholinergic neurons in the nucleus basalis magnocellularis and the ability to acquire an inhibitory avoidance response in the step-down ...
Arianna Bellucci, Ilaria Luccarini, Carla Scali, Costanza Prosperi, Maria Grazia Giovannini, Giancarlo Pepeu, Fiorella Casamenti   +6 more
doaj   +1 more source