Results 41 to 50 of about 24,506 (124)

A physical model of nicotinic ACh receptor kinetics [PDF]

arXiv, 2008
We present a new approach to nicotinic receptor kinetics and a new model explaining random variabilities in the duration of open events. The model gives new interpretation on brief and long receptor openings and predicts (for two identical binding sites) the presence of three components in the open time distribution: two brief and a long.
arxiv  

The Channel Capacity of Channelrhodopsin and Other Intensity-Driven Signal Transduction Receptors [PDF]

arXiv, 2018
Biological systems transduce signals from their surroundings through a myriad of pathways. In this paper, we describe signal transduction as a communication system: the signal transduction receptor acts as the receiver in this system, and can be modeled as a finite-state Markov chain with transition rates governed by the input signal.
arxiv  

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes.
Hongtao Liu, J. Hofmann, I. Fish, B. Schaake, K. Eitel, A. Bartuschat, J. Kaindl, H. Rampp, A. Banerjee, H. Hübner, M. Clark, S. Vincent, J. Fisher, M. Heinrich, K. Hirata, Xiangyu Liu, R. Sunahara, B. Shoichet, B. Kobilka, P. Gmeiner   +19 more
semanticscholar   +1 more source

Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes [PDF]

arXiv, 2019
At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates to give rise to rapid muscle movement. While lipid domains have maintained nAChR aggregates in-vitro, their specific roles in nAChR clustering are currently unknown. In the present study, we carried out coarse-grained molecular dynamics simulations (CG-MD)
arxiv  

BK channel β1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization

Journal of Physiology, 2011
Non‐technical summary  Parasympathetic nerve activation of M3 and M2 muscarinic acetylcholine receptors initiates and modulates calcium release from the sarcoplasmic reticulum to control airway smooth muscle contraction.
I. Semenov, Bin Wang, J. Herlihy, R. Brenner   +3 more
semanticscholar   +1 more source

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms *

Journal of Biological Chemistry, 1995
The phenomenon of acute desensitization of G-protein-coupled receptors has been associated with several events, including receptor phosphorylation, loss of high affinity agonist binding, receptor:G-protein uncoupling, and receptor internalization ...
R. Pals‐Rylaarsdam, Yirong Xu, P. Witt‐Enderby, J. Benovic, Marlene Hosey‡i   +4 more
semanticscholar   +1 more source

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Members of the muscarinic acetylcholine receptor family (M1-M5) are known to be involved in a great number of important central and peripheral physiological and pathophysiological processes.
J. Gomeza, H. Shannon, E. Kostenis, C. Felder, Lu Zhang, J. Brodkin, A. Grinberg, Hui Sheng, J. Wess   +8 more
semanticscholar   +1 more source

Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]

arXiv, 2018
Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv  

Synergistic Regulation of m2 Muscarinic Acetylcholine Receptor Desensitization and Sequestration by G Protein-coupled Receptor Kinase-2 and β-Arrestin-1*

Journal of Biological Chemistry, 1997
The m2 muscarinic acetylcholine receptor (m2 mAChR) belongs to the superfamily of G protein-coupled receptors and is regulated by many processes that attenuate signaling following prolonged stimulation by agonist. We used a heterologous expression system
M. L. Schlador, N. Nathanson
semanticscholar   +1 more source

Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome

Molecular Pain, 2018
Complex regional pain syndrome is an extremely painful condition that develops after trauma to a limb. Complex regional pain syndrome exhibits autoimmune features in part mediated by autoantibodies against muscarinic‐2 acetylcholine (M2) receptor.
V. Shubayev, A. Strongin, T. Yaksh
semanticscholar   +1 more source