British Journal of Pharmacology, Volume 182, Issue 1, Page 104-130, January 2025.Abstract Background and Purpose Fentanyl analogues have been implicated in many cases of intoxication and death with overdose worldwide. The aim of this study is to investigate the pharmaco‐toxicology of two fentanyl analogues: butyrylfentanyl (BUF) and 4‐fluorobutyrylfentanyl (4F‐BUF).
Sabrine Bilel +10 more
wiley +1 more source
Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]
, 2018 Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi +13 more
core +2 more sources
Angewandte Chemie International Edition, Volume 63, Issue 52, December 20, 2024.l‐(+)‐Muscarine is one of the most toxic mushroom metabolites. We identified its congener 4’‐phosphomuscarine in the fool's funnel and in various fiber cap mushrooms, and chemically and pharmacologically characterized this new natural product. As hydrolysis of its ester releases muscarine, our results help estimate the true toxin content of these ...
Sebastian Dörner +7 more
wiley +1 more source
Advancing Neural Networks: Innovations and Impacts on Energy Consumption
Advanced Electronic Materials, Volume 10, Issue 12, December 2024.A comparative study of ANN and SNN including biological neural networks is presented. An inefficiency of 5–8 orders of magnitude is indicated for modern ANN approaches, with the worst Transformer ANN over CPU. The most efficient implementation of the SNNs is biological neurons with only 100 fJ per synaptic weight update, next is inorganic Mosaic ...
Alina Fedorova +9 more
wiley +1 more source
Regulation of Src Family Tyrosine Kinases in the Rat Striatum by Muscarinic Acetylcholine Receptors [PDF]
, 2017 Acetylcholine is an important neurotransmitter in the mammalian brain. This transmitter binds to muscarinic acetylcholine receptors (mAChR) to regulate activity of a variety of intracellular signaling molecules.
Faris, Hunter
core
Morphologic evaluation and Ca2+ mobilization by glicose and acetylcholine in human pancreatic cells [PDF]
, 2007 AIMS: The proposal of this study was to analyze morphology of the organelles and cytoskeleton in human pancreatic cells cultured and the mobilization of the cytosolic calcium ([Ca2+]c) in response to glucose and ACh by fluorimetry method.
Cardoso, Daniela Espinha +5 more
core +3 more sources
The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]
, 2018 Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth +6 more
core +2 more sources
Photo‐BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor
Angewandte Chemie International Edition, Volume 63, Issue 47, November 18, 2024.Photoswitchable allosteric modulators for the Class A of a G protein‐coupled receptor, themuscarinic acetylcholine receptor subtype 1 (M1R) were developed based on the allosteric modulator benzyl quinolone carboxylic acid (BQCA) exploiting its flat structure–activity relationships.
Hubert Gerwe +8 more
wiley +1 more source
Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor [PDF]
, 2016 Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid (BQCA). In
Capuano, Ben +8 more
core +2 more sources
Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life [PDF]
, 2012 Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism.
Clarice Gravena +3 more
core +1 more source