Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.Abstract BACKGROUND Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including increased risk in dementia. Pharmacoepidemiology studies from various populations report associations between specific anticholinergic classes – antidepressants and bladder antimuscarinics – and increased dementia incidence.
Tiara A. Schwarze‐Taufiq +7 more
wiley +1 more source
Morphologic evaluation and Ca2+ mobilization by glicose and acetylcholine in human pancreatic cells [PDF]
, 2007 AIMS: The proposal of this study was to analyze morphology of the organelles and cytoskeleton in human pancreatic cells cultured and the mobilization of the cytosolic calcium ([Ca2+]c) in response to glucose and ACh by fluorimetry method.
Cardoso, Daniela Espinha +5 more
core +3 more sources
British Journal of Pharmacology, Volume 182, Issue 1, Page 104-130, January 2025.Abstract Background and Purpose Fentanyl analogues have been implicated in many cases of intoxication and death with overdose worldwide. The aim of this study is to investigate the pharmaco‐toxicology of two fentanyl analogues: butyrylfentanyl (BUF) and 4‐fluorobutyrylfentanyl (4F‐BUF).
Sabrine Bilel +10 more
wiley +1 more source
Adrenergic receptors. Models for regulation of signal transduction processes. [PDF]
, 1990 Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene.
Caron, MG +3 more
core +1 more source
G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]
, 2009 Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core
Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor [PDF]
, 2016 Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid (BQCA). In
Capuano, Ben +8 more
core +2 more sources
Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]
, 2010 To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core +2 more sources
Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli [PDF]
, 2000 The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP)
Furukawa, H., Haga, T.
core +1 more source
Age-related changes in afferent pathways and urothelial function in the male mouse bladder [PDF]
, 2013 Key points •The prevalence of bladder conditions such as overactive bladder syndrome and urinary incontinence significantly increases with age, but how bladder function is altered by ageing is unclear.
Christopher Chapple +7 more
core +1 more source
Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. [PDF]
, 2013 Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
Almasy, Laura +20 more
core +2 more sources