Results 91 to 100 of about 19,182 (246)
Cholinergic Responses of Ophthalmic Arteries in M3and M5Muscarinic Acetylcholine Receptor Knockout Mice [PDF]
Investigative Opthalmology & Visual Science, 2009 To determine the functional role of M(3) and M(5) muscarinic acetylcholine receptor subtypes in ophthalmic arteries using gene-targeted mice.Muscarinic receptor gene expression was quantified in murine ophthalmic arteries using real-time PCR. To test the functional relevance of M(3) and M(5) receptors, ophthalmic arteries from mice deficient in either ...
Lars Choritz +9 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2009 .: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga +4 more
doaj
Cholinergic switch between two types of slow waves in cerebral cortex [PDF]
Cerebral Cortex 2019, 2018 Sleep slow waves are known to participate in memory consolidation, yet slow waves occurring under anesthesia present no positive effects on memory. Here, we shed light onto this paradox, based on a combination of extracellular recordings in vivo, in vitro, and computational models.
arxiv +1 more source
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
Geriatrics &Gerontology International, Volume 25, Issue 4, Page 520-527, April 2025.Anticholinergic burden, quantified using the Japanese Anticholinergic Drug Risk Scale, may be a predictor of frailty and sarcopenia in community‐dwelling older adults. Effective evaluation and management of anticholinergic burden using the Japanese Anticholinergic Drug Risk Scale are crucial for promoting healthy aging and mitigating adverse health ...
Tomoki Tanaka +4 more
wiley +1 more source
Molecular OncologyMicrotubule‐targeting agents represent one of the most successful classes of anticancer agents. However, the development of drug resistance and the appearance of adverse effects hamper their clinical implementation.
Yao‐Yu Hsieh +2 more
doaj +1 more source
A factor graph EM algorithm for inference of kinetic microstates from patch clamp measurements [PDF]
arXiv, 2021 We derive a factor graph EM (FGEM) algorithm, a technique that permits combined parameter estimation and statistical inference, to determine hidden kinetic microstates from patch clamp measurements. Using the cystic fibrosis transmembrane conductance regulator (CFTR) and nicotinic acetylcholine receptor (nAChR) as examples, we perform {\em Monte Carlo}
arxiv
Regulation of Src Family Tyrosine Kinases in the Rat Striatum by Muscarinic Acetylcholine Receptors [PDF]
, 2017 Acetylcholine is an important neurotransmitter in the mammalian brain. This transmitter binds to muscarinic acetylcholine receptors (mAChR) to regulate activity of a variety of intracellular signaling molecules.
Faris, Hunter
core
Functional Characterization of the Epidermal Cholinergic System In Vitro [PDF]
, 2006 The aim of this study was to analyze the influence of cholinergic and anticholinergic drugs on epidermal physiology using organotypic cocultures (OTCs). Blocking of all acetylcholine receptors (AChRs) by combined treatment with mecamylamine and atropine ...
Booken, Dirk +8 more
core +1 more source
Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M1 – M5 muscarinic acetylcholine receptors [PDF]
Bioorganic & Medicinal Chemistry Letters, 2019 Novel quinuclidinyl N-phenylcarbamate analogs were synthesized, and binding affinities at M1-M5 muscarinic acetylcholine receptor (mAChR) subtypes were determined using Chinese hamster ovary (CHO) cell membranes stably expressing one specific subtype of human mAChR. Although not subtype selective, the lead analog (±)-quinuclidin-3-yl-(4-fluorophenethyl)
Na-Ra Lee +5 more
openaire +3 more sources