Results 61 to 70 of about 5,131 (212)
Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons [PDF]
, 2002 The cholinergic system is thought to play an important role in hippocampal-dependent learning and memory. However, the mechanism of action of the cholinergic system in these actions in not well understood.
Power, JM, Sah, P
core +2 more sources
Frontiers in Cellular Neuroscience, 2018 The main olfactory epithelium (MOE) functions to detect odor molecules, provide an epithelial surface barrier, and remove xenobiotics from inhaled air.
Ziying Fu +3 more
doaj +1 more source
GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger
British Journal of Pharmacology, Volume 182, Issue 17, Page 3975-3989, September 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng +3 more
wiley +1 more source
Frontiers in Pharmacology, 2013 Urothelial cells, myofibroblasts, and smooth muscle cells are important cell types contributing to bladder function. Multiple receptors including muscarinic (M3/M5), tachykinin (NK1/NK2) and purinergic (P2X1/P2Y6) receptors are involved in bladder motor ...
Forough eBahadory +3 more
doaj +1 more source
Selective inhibition of M5muscarinic acetylcholine receptors attenuates cocaine self‐administration in rats [PDF]
Addiction Biology, 2017 AbstractCocaine use disorder (CUD) remains a debilitating health problem in the United States for which there are no Food and Drug Administration‐approved treatment options. Accumulating anatomical and electrophysiological evidence indicates that the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) plays a critical role in the regulation of the
Barak W. Gunter +5 more
openaire +3 more sources
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling [PDF]
, 2017 Satiety, rather than all or none, can instead be viewed as a cumulative decrease in the drive to eat that develops over the course of a meal. The nucleus accumbens (NAc) is known to play a critical role in this type of value reappraisal, but the ...
Aitta-aho, Teemu Heikki Juhani +8 more
core +2 more sources
Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
Pharmacological ResearchΔ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova +2 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]
, 2011 Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago +3 more
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