Results 61 to 70 of about 20,015 (223)

Dopamine Signaling in Dorsal Versus Ventral Striatum: The Dynamic Role of Cholinergic Interneurons [PDF]

, 2011
Mesostriatal dopaminergic neurons and striatal cholinergic interneurons participate in signaling the motivational signifcance of environmental stimuli and regulate striatal plasticity. Dopamine (DA) and acetylcholine (ACh) have potent interactions within
Sarah Threlfell, Stephanie Jane Cragg
core   +3 more sources

Carbachol‐induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor [PDF]

FEBS Letters, 1989
Reverse transformation was induced in Chinese hamster ovary (CHO) cells transfected with and stably expressing the m5 subtype of the muscarinic acetylcholine receptor when stimulated with the muscarinic agonist, carbachol. Atropine, a muscarinic antagonist, blocked the carbachol‐stimulated reverse transformation.
Felder, Christian C., Ma, Alice L., Conklin, Bruce R.   +2 more
openaire   +2 more sources

On the role of G protein-coupled receptors oligomerization [PDF]

, 2013
The existence of a supramolecular organization of the G protein-coupled receptor (GPCR) is now being widely accepted by the scientific community.
Ahern, Siobhán, Ciruela Alférez, Francisco, Fernández Dueñas, Víctor, Gómer Soler, Maricel   +3 more
core   +2 more sources

Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor

Journal of Medicinal Chemistry
While the muscarinic acetylcholine receptor mAChR subtype 5 (M5) has been studied over decades, recent findings suggest that more in-depth research is required to elucidate a thorough understanding of its physiological function related to neurological ...
Jinming Li, Douglas L. Orsi, Julie L Engers, Madeline F Long, Rory A. Capstick, Mallory A Maurer, Christopher C Presley, P. Vinson, Alice L. Rodriguez, Allie Han, Hyekyung P. Cho, Sichen Chang, Megan Jackson, M. Bubser, A. L. Blobaum, Olivier Boutaud, Michael A. Nader, C. Niswender, P. J. Conn, Carrie K Jones, C. Lindsley, Changho Han   +21 more
semanticscholar   +1 more source

Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M1 – M5 muscarinic acetylcholine receptors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2019
Novel quinuclidinyl N-phenylcarbamate analogs were synthesized, and binding affinities at M1-M5 muscarinic acetylcholine receptor (mAChR) subtypes were determined using Chinese hamster ovary (CHO) cell membranes stably expressing one specific subtype of human mAChR. Although not subtype selective, the lead analog (±)-quinuclidin-3-yl-(4-fluorophenethyl)
Na-Ra Lee, Satheesh Gujarathi, Shobanbabu Bommagani, Kiranbabu Siripurapu, Guangrong Zheng, Linda P. Dwoskin   +5 more
openaire   +2 more sources

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1531-1546, 15 February 2026.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Expression and Function of the Cholinergic System in Immune Cells

Frontiers in Immunology, 2017
T and B cells express most cholinergic system components—e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively).
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

Alpha‐Ketoglutarate Regulates Intestinal Motility and Health by OXGR1 in Nitrergic Neuron of Enteric Nervous System

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an increased count of intestinal flora.
Guli Xu, Jingjing Zhou, Pingwen Xu, Ishwari Gyawali, Chang Xu, Jinping Yang, Zewei Ma, Dan Du, Qingyan Jiang, Gang Shu   +9 more
wiley   +1 more source

Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. [PDF]

, 2006
The CHRM2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing.
Boomsma D.I., Cherny S.S., D. I. Boomsma, D. Posthuma, E. J. C. de Geus, Hulme E.C., J. C. Polderman, Levey A.I., Linder C.C., M. F. Gosso, M. van Belzen, Meulenbelt I., Miller S.A., Montagutelli X., P. Heutink, Quirion R., Wechsler D., Wechsler D., Wei J., Wess J., Zhang W.   +20 more
core   +3 more sources

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source