Results 111 to 120 of about 406,175 (317)
The mechanisms of calcium homeostasis and signalling in the lens [PDF]
, 2008 Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1989 We have used the hippocampal slice preparation to investigate the regulation of protein tyrosine phosphorylation in brain. After pharmacological treatment of intact slices, proteins were separated by electrophoresis, and levels of protein tyrosine ...
K. R. Stratton +3 more
semanticscholar +1 more source
The effects of agonists on the components of the cardiac muscarinic receptor [PDF]
British Journal of Pharmacology, 1987 The binding of eleven agonists to muscarinic receptors in the rat heart has been measured in competition with [3H]‐N‐methylscopolamine. Full analysis of binding required the resolution of three components (SH, H and L). The proportion of the H component was independent of agonist structure.
openaire +3 more sources
Journal of Oral Pathology &Medicine, EarlyView.ABSTRACT Introduction There has been a significant increase in antipsychotic usage, particularly belonging to second‐generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear.
Dileep Sharma +7 more
wiley +1 more source
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]
, 2005 The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC +6 more
core +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
PLoS Pathogens, 2015 Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus ...
Matthew Darby +11 more
doaj +1 more source
The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents [PDF]
, 1977 Daniel Cavey +2 more
openalex +1 more source
Neurogastroenterology &Motility, EarlyView.Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz +4 more
wiley +1 more source
Model-based prediction of muscarinic receptor function from auditory mismatch negativity responses
NeuroImage, 2021 Drugs affecting neuromodulation, for example by dopamine or acetylcholine, take centre stage among therapeutic strategies in psychiatry. These neuromodulators can change both neuronal gain and synaptic plasticity and therefore affect electrophysiological
Dario Schöbi +8 more
doaj