Results 191 to 200 of about 51,230 (302)

M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion [PDF]

, 2007
Pingfang Song, Harmanjatinder S. Sekhon, Allison Lu, Juan Arredondo, David Sauer, Courtney Gravett, Gregory P. Mark, Sergei A. Grando, Eliot R. Spindel   +8 more
openalex   +1 more source

Piperazine Derivatives Attenuate Scopolamine‐Induced Memory Deficits by Modulating Neuroinflammation and Oxidative Stress via the NF‐κB/TNF‐α/COX‐2 Pathway

ChemistrySelect, Volume 10, Issue 25, July 4, 2025.
Piperazine derivatives 2b, 2f, and 2h reduce neuroinflammation, oxidative stress, and memory impairment by modulating COX‐2, p‐NF‐κB, and TNF‐α pathways, showing promise as lead compounds for neurodegenerative disease drug development. Abstract Oxidative stress‐induced neuro‐inflammatory events are common in neurodegenerative illnesses, addressing ...
Sadaf Fardoos, Sidra Kaleem, Syed Muzzammil Masaud, Faryal Jahan, Humaira Nadeem, Muhammad Afzal, Abdulwahed Fahad Alrefaei, Eman Alshehri, Sajid Ali   +8 more
wiley   +1 more source

Patient-reported outcomes of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in individuals with COPD

International Journal of COPD, 2019
Charlie Strange,1 Valery Walker,2 Michael DePietro,3 Junliang Tong,2 Jonathan Kurlander,2 Maureen Carlyle,2 Lauren A Millette,3 Eric Wittbrodt41Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA ...
Strange C, Walker V, DePietro M, Tong J, Kurlander J, Carlyle M, Millette LA, Wittbrodt E   +7 more
doaj  

Nα-nitro L-arginine methylester and other alkyl esters of L-arginine are muscarinic antagonists

, 1992
Dennis J. Cheek, Delrae M. Eckman, Iain L. O. Buxton, Kathleen D. Keef   +3 more
openalex   +1 more source

Sleep-Predominant Lowering of Ambulatory Blood Pressure by Bedtime Inhalation of a Novel Muscarinic M3 Receptor Antagonist: A New “Bronchoantihypertensive” Strategy Targeting the Lung in Hypertension with Chronic Obstructive Pulmonary Disease [PDF]

, 2008
Kazuomi Kario, Hideyuki Uno, Kazuyuki Shimada   +2 more
openalex   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Cholinergic neurons in the dorsomedial hypothalamus regulate food intake

Molecular Metabolism, 2017
Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong, Dong Kun Lee, Young-Hwan Jo   +2 more
doaj  

Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study. [PDF]

Clin Pharmacol Drug Dev, 2020
Borin MT, Barnes CN, Darpo B, Pendyala S, Xue H, Bourdet DL.   +5 more
europepmc   +1 more source

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning [PDF]

, 2009
Douglas J. Sheffler, Richard D. Williams, Thomas M. Bridges, Zixiu Xiang, Alexander S. Kane, Nellie Byun, Satyawan Jadhav, Mathew M. Mock, Fang Zheng, L. Michelle Lewis, Carrie K. Jones, Colleen M. Niswender, Charles D. Weaver, Craig W. Lindsley, P. Jeffrey Conn   +14 more
openalex   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source