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Long-acting muscarinic M3 receptor antagonists.
Expert opinion on therapeutic patents, 2010A series of 10 closely related patent applications define Theravance's approach to the development of long-acting M(3) selective antagonists for the treatment of chronic obstructive pulmonary disease. The applications illustrate a modular approach to the design of such agents, comprising a muscarinic pharmacophore attached to a second, less ...
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Dual-acting beta2 agonists/muscarinic antagonists.
Expert opinion on therapeutic patents, 2010Bifunctional aromatic derivatives that act as both beta(2) agonists and muscarinic receptor antagonists are claimed. The compounds use two separate pharmacophoric groups, coupled by a long lipohilic chain, to provide the desired biological activities and with the aim of providing a long duration of action.
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Darifenacin, A selective muscarinic M3 antagonist
Pharmacological Research, 1995R.M. Wallis +5 more
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The conformations of muscarinic antagonists.
British journal of pharmacology, 1970P, Pauling, T J, Petcher
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Muscarinic Cholinergic Receptor Agonists and Antagonists
2013Michael E. Ragozzino, Holden D. Brown
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