Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]
Geriatr Gerontol IntABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Mogi M +4 more
europepmc +2 more sources
Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts [PDF]
, 2019 We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.(SFRH/BPD/115169/2016) funded by Fundação para a Ciência e Tecnologia (FCT); ERDF (European Regional ...
Afonso, Ivete +68 more
core +3 more sources
A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto +12 more
wiley +1 more source
The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]
, 2009 Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen +2 more
core +1 more source
Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus
Epilepsia, EarlyView.Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun +6 more
wiley +1 more source
Spreading depolarization and its influence on epileptiform activity
Epilepsia, EarlyView.Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque +2 more
wiley +1 more source
Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma? [PDF]
Drugs, 2023 Cazzola M, Rogliani P, Matera MG.
europepmc +1 more source
Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]
, 2017 Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J +3 more
core +2 more sources
Separation and simultaneous estimation of enantiomers and Diastereomers of muscarinic receptor antagonist Solifenacin using stability‐indicating Normal‐phase HPLC technique with chiral stationary phase amylose tris‐(3,5‐dimethylphenylcarbamate) [PDF]
, 2023 Niroja Vadagam +4 more
openalex +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source