Results 81 to 90 of about 18,712 (165)

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

Muscarinic Receptor Agonists and Antagonists: Effects on Cancer [PDF]

, 2011
Many epithelial and endothelial cells express a cholinergic autocrine loop in which acetylcholine acts as a growth factor to stimulate cell growth. Cancers derived from these tissues similarly express a cholinergic autocrine loop and ACh secreted by the cancer or neighboring cells interacts with M3 muscarinic receptors expressed on the cancer cells to ...
openaire   +3 more sources

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]

, 2020
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

Dupilumab Efficacy and Safety in Patients With Persistent Asthma: Asia–Pacific Region

Clinical &Experimental Allergy, EarlyView.
Asthma prevalence is increasing in the Asia–Pacific region, and this population is frequently underrepresented in phase 3 clinical studies. We demonstrate Dupilumab's efficacy and safety among patients with uncontrolled moderate‐to‐severe type 2 asthma.
Qingling Zhang, Nanshan Zhong, Sahajal Dhooria, Xiuhua Fu, Haohui Fang, Jie Lin, Shuyang Zhu, Elizabeth Laws, Yi Wang, Vivian Li, Chih‐Chi Hu, Jennifer Maloney, Raolat M. Abdulai, Lacey B. Robinson   +13 more
wiley   +1 more source

Hyperhidrosis: don't sweat it

Internal Medicine Journal, EarlyView.
Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Oral Health in Individuals with Severe Mental Illness on Second‐Generation Antipsychotics—A Scoping Review

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Introduction There has been a significant increase in antipsychotic usage, particularly belonging to second‐generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear.
Dileep Sharma, Oliver Higgins, Aleksander Sawicki, Poornima Ramamurthy, Belinda Field, Paul Hussein, Kiran Singh, Sarbin Ranjitkar   +7 more
wiley   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source