Results 81 to 90 of about 572,756 (326)
BMC Urology, 2020 Background DA-8010 is a novel compound developed for the treatment of overactive bladder (OAB) and urinary incontinence. The aims of this study were to investigate the effects of DA-8010 on OAB in a rat model.
Jin Bong Choi +8 more
doaj +1 more source
Long-Term Efficacy of Mirabegron Add-On Therapy to Antimuscarinic Agents in Patients With Spinal Cord Injury [PDF]
Annals of Rehabilitation Medicine, 2019 Objective To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study.
Seok-Hee Han +4 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori +15 more
wiley +1 more source
The Effect Of A Muscarinic Antagonist On The Lipase Activity
, 2015 Lipases constitute one of the most important groups of industrial enzymes that catalyze the hydrolysis of triacylglycerol to glycerol and fatty acids. Muscarinic antagonist relieves smooth muscle spasm of the gastrointestinal tract and effect on the cardiovascular system.
Zohreh Bayat, Dariush Minai-Tehrani
openaire +1 more source
Mass Production of Uniform Embryoid Bodies by Acoustic Standing Waves
Small Methods, EarlyView.This innovative method for the generation of human induced pluripotent stem cell (hiPSC)‐derived embryoid bodies provides a scalable, flexible and cell‐friendly approach for the mass production of highly uniform cell clusters. It maintains the high cell viability and pluripotent state of hiPSCs while allowing successful differentiation into ...
Johannes Hahn +7 more
wiley +1 more source
Cell Reports, 2019 Summary: Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and the pathogenesis of tumor progression. We investigated the innervation of LVs and the response to agonists and antagonists of the autonomic nervous system in
Samia B. Bachmann +8 more
doaj +1 more source
Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors [PDF]
, 2015 An anti-Hebbian form of LTP is observed at excitatory synapses made with some hippocampal interneurons. LTP induction is facilitated when postsynaptic interneurons are hyperpolarized, presumably because Ca(2+) entry through Ca(2+)-permeable glutamate ...
Kullmann, DM +3 more
core +1 more source
United European Gastroenterology Journal, EarlyView.ABSTRACT Introduction Abdominal distension is an objective visible sign of increased abdominal girth. Bloating is a feeling of abdominal fullness and discomfort. Bloating may be associated or not with abdominal distension. Bloating and abdominal distension are among the most commonly reported gastrointestinal symptoms and may be associated with both ...
Chloé Melchior +20 more
wiley +1 more source
Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
Pharmacological ResearchΔ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2014 .: The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding assay in rat brain membranes.
Yuji Odagaki +2 more
doaj +1 more source