Results 121 to 130 of about 85,643 (234)
The role of agomelatine in appetite regulation and body weight in rats
Experimental Physiology, EarlyView.Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz +3 more
wiley +1 more source
Imposed expiratory resistance, dynamic hyperinflation and locomotor power and fatigue
Experimental Physiology, EarlyView.Abstract Expiratory flow limitation results in dynamic hyperinflation, dyspnoea and premature exercise intolerance. We aimed to measure whether expiratory resistance reduces locomotor power via limiting maximal voluntary motor activity, exacerbating muscle fatigue, or both.
Jonathan Cunha +4 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Acute myocardial infarction is a leading cause of morbidity and mortality, with ischaemia–reperfusion (I/R) injury exacerbating myocardial damage. Vagus nerve stimulation (VNS) has been reported to exert cardioprotective effects, but its efficacy in preconditioning against I/R injury requires further investigation.
Feng Hu +10 more
wiley +1 more source
Are Voltage Sensors Really Embedded in Muscarinic Receptors? [PDF]
Int J Mol Sci, 2023 Cohen-Armon M.
europepmc +1 more source
Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental Physiology, EarlyView.Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract The contribution of persistent inward currents (PICs) to motoneuron firing in the lower limb typically increases after a remote handgrip contraction, believed to result from diffuse serotonergic input increases in spinal cord. We investigated whether handgrip contraction intensity, duration and/or impulse would affect PIC estimates in tibialis
Lucas Ugliara +3 more
wiley +1 more source
Glial cells in the heart: Implications for their roles in health and disease
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya +2 more
wiley +1 more source
Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAB and Muscarinic Receptors. [PDF]
Pharmaceuticals (Basel), 2023 Opretzka LCF +8 more
europepmc +1 more source
Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation
The Journal of Physiology, EarlyView.Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson +7 more
wiley +1 more source
Selective Activation of M1 Muscarinic Receptors Attenuates Human Colon Cancer Cell Proliferation. [PDF]
Cancers (Basel), 2023 Sundel MH +7 more
europepmc +1 more source