Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental Physiology, EarlyView.Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source
Glial cells in the heart: Implications for their roles in health and disease
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya +2 more
wiley +1 more source
The muscarinic receptor subtype in mouse pancreatic B‐cells [PDF]
, 1988 Jean‐Claude Henquin, Myriam Nenquin
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Subtypes of muscarinic receptor on cholinergic nerves and atrial cells of chicken and guinea‐pig hearts [PDF]
, 1988 D. Jeck +3 more
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Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation
The Journal of Physiology, EarlyView.Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson +7 more
wiley +1 more source
Fusion with Promiscuous Gα16 Subunit Reveals Signaling Bias at Muscarinic Receptors. [PDF]
Int J Mol Sci, 2021 Randáková A +6 more
europepmc +1 more source
PRESYNAPTIC MUSCARINIC RECEPTORS INHIBITING ACTIVE ACETYLCHOLINE RELEASE IN THE BULLFROG SYMPATHETIC GANGLION [PDF]
, 1982 K. Koketsu, Masanobu Yamada
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Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.Abstract Aim Olanzapine and clozapine are second‐generation antipsychotics commonly associated with metabolic side effects. In Japan, olanzapine is designated as “principally contraindicated” for patients with diabetes, while clozapine is “used with caution,” despite similar pharmacological profiles.
Keigo Onda +2 more
wiley +1 more source
Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders. [PDF]
Biomedicines, 2022 Johnson CR +4 more
europepmc +1 more source