Results 201 to 210 of about 85,643 (234)

Constitutively active muscarinic receptors

Life Sciences, 2001
Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
T A, Spalding, E S, Burstein
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Desensitization of Muscarinic Receptors

Receptors and Channels, 2004
When Chinese hamster ovary cells transfected with the gene for M(3)-muscarinic receptors were stimulated with carbachol continuously for 30 min, the response at the end of the stimulation period was about 20% of the early response (2-3 min after the start of the stimulation).
N, Fraeyman, J, van Emmelo, R H, Paulssen, K, Vermis   +3 more
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Muscarinic Receptors in Schizophrenia

Current Molecular Medicine, 2003
An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have shown there are regionally specific decreases in selective muscarinic receptors in the CNS of subjects ...
B, Dean, F P, Bymaster, E, Scarr
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Muscarinic receptors in pineal

Life Sciences, 1980
Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
R L, Taylor, M L, Albuquerque, D R, Burt
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Presynaptic muscarinic cholinergic receptors

Nature, 1978
IN the isolated rabbit heart, acetylcholine inhibits the release of noradrenaline evoked by nicotinic drugs1, by KCl (ref. 2) and by sympathetic nerve stimulation3. The release of noradrenaline in response to sympathetic nerve stimulation in the rabbit heart was found to be reduced by para-sympathomimetic agonists, and atropine antagonised this effect ...
V K, Sharma, S P, Banerjee
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Muscarinic Receptor Assays

Current Protocols in Pharmacology, 1999
AbstractIn the central and peripheral nervous systems, the actions of acetylcholine are mediated by families of ligand gated ion channels and metabotropic receptors. The latter family is composed of muscarinic receptors, since they are selectively activated by muscarine and antagonized by atropine. Five muscarinic receptor subtypes have been identified
Richard M. Eglen, Agnes Choppin, Nikki Watson, Sharath S. Hegde   +3 more
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Muscarinic receptors

2002
Abstract The pharmacology of acetylcholine is in many ways a very old subject. The use of antimuscarinic plant extracts as both poisons and therapies can be traced back to ancient times. Thus, Linnaeus gave the systematic name Atropa belladonna to the deadly nightshade, in homage to Atropos of Greek mythology, who cuts the thread of life,
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Muscarinic Receptors

Nature, 1961
A H, BECKETT, N J, HARPER, J W, CLITHEROW, E, LESSER   +3 more
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CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment

This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...
Abraham, Fisher, Allan I, Levey
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Muscarinic Receptor Antagonists

Pulmonary Pharmacology & Therapeutics, 1999
N, Watson, R M, Eglen
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