Results 141 to 150 of about 8,003 (176)
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Stimulation of food intake by muscimol and beta endorphin
Neuropharmacology, 1977Abstract Muscimol, a GABA agonist, or beta-endorphin, an endogenous opiate receptor agonist, stimulated food intake in satiated rats when injected into the ventromedial hypothalamus. A similar effect was elicited by norepinephrine. Eating induced by muscimol was inhibited by bicuculline but not by naltrexone or phentolamine.
L, Grandison, A, Guidotti
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Effects of muscimol and flurazepam on the sleep EEG in the rat
Life Sciences, 1990In order to assess the possible role of GABA receptor function in the hypnotic property of benzodiazepines, we have examined the sleep EEG in rats given the GABA agonist muscimol, alone and in combination with flurazepam. Muscimol 0.05 and 0.1 mg/kg IP failed to alter sleep latency or total sleep time, and did not interact with the sleep-enhancing ...
W B, Mendelson, J V, Martin
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Anticonvulsant and behavioral effects of muscimol in immature rats
Brain Research, 2014Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABAA receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and side effects on motor activities.
Pavel, Mareš +2 more
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Effect of muscimol on dopamine metabolism of the rat hypothalamus
Experientia, 1980Muscimol, a potent GABA receptor agonist, produced increases in DOPAC and dopamine concentrations in the rat hypothalamus. GABAergic receptors, therefore, modulate hypothalamic dopaminergic neurones.
A L, Gundlach, P M, Beart
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Autoradiographic localization of [3H]muscimol in the cat retina
Brain Research, 1981In the cat retina, [3H]muscimol is localized in 5 morphologically distinct subpopulations of neurons with cell bodies in the amacrine layer and in other neurons located in the ganglion cell layer. Müller cells are unlabeled. The labeled subpopulations in the amacrine layer correspond to the subpopulations which also exhibit preferential uptake of [3H ...
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Muscimol as an antagonist of chemical convulsants.
Archives internationales de pharmacodynamie et de therapie, 1982Muscimol (MU) was tested on mice for anticonvulsive action against chemical convulsants. 3-Mercaptopropionic acid (3-MP) was more sensitive to inhibition by MU (1.5 mg/kg) than was either pentylenetretrazol (PTZ) or bicuculline (BIC); picrotoxin (PIC) and kainic acid were not measurably antagonized; aminophylline was potentiated.
W E, Stone, M J, Javid
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Use of 3H-muscimol for GABA receptor studies
Nature, 1978γ-AMINOBUTYRIC ACID (GABA) is a major transmitter in the mammalian central nervous system (CNS)1,2 and studies of synaptic receptors for neurotransmitters have been useful in many areas of neuropharmacology3,4. Although GABA receptors can be studied using 3H-GABA itself5–7, a ligand which does not bind to GABA uptake sites would be valuable for ...
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[Ventrobulbular hypotensive action of muscimol].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1979Muscimol, a rigid analogue of GABA has been injected in the CNS of urethane anesthetized, normotensive cats. Injected either intracisternally (1 or 2 microgram/kg, 0.05 ml) or directly by microinjection in a restricted ventrolateral region of the brain stem (0.5 or 1 microgram/kg, 0.5 microliter), muscimol induced hypotension and bradycardia.
P, Bousquet +3 more
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Muscimol: GABA agonist therapy in schizophrenia
American Journal of Psychiatry, 1978C A, Tamminga, J W, Crayton, T N, Chase
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