Results 251 to 260 of about 451,246 (307)

Deficiency of p27^kip1, a Cyclin-Dependent Kinase Inhibitor, Accelerates Topical Elastase/3-Aminopropionitrile Fumarate Salt-Induced Abdominal Aortic Aneurysm Development in Mice.

J Vasc Res
Kamada K, Niu H, Kikuchi S, Azuma N, Tang GL.   +4 more
europepmc   +1 more source

Multiomic profiling reveals pericyte and smooth muscle cell contributions to CADASIL pathology in cell-specific Notch3 mutant mice

Huang Y, Clementel V, Zhang M, Martinez K, Martinez K, Spillard G, Torres-Sepulveda C, Kisler K, Coba MP, Rust R.   +9 more
europepmc   +1 more source

Vascular smooth muscle cells in atherosclerosis [PDF]

Nature Reviews Cardiology, 2019
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and ...
Helle F. Jørgensen, Murray C H Clarke, Martin R Bennett   +2 more
exaly   +5 more sources

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Leptin and Vascular Smooth Muscle

Current Vascular Pharmacology, 2006
Leptin has received extensive attention as an endogenously produced satiety factor. Although once considered to be solely derived from adipose tissue, it is now apparent that leptin can be produced by various tissues including those comprising the cardiovascular system such as blood vessels and cardiomyocytes. Moreover, leptin receptors (OBR) have been
Asad Zeidan, Morris Karmazyn
openaire   +3 more sources

Vascular Smooth Muscle Energetics

Journal of Cardiovascular Pharmacology, 1984
ATP utilization (delta approximately P) during an isometric contraction has been studied in terms of both measurements of oxygen consumption and lactate production as well as of the tissue nucleotide and metabolite levels. The contribution of breakdown of preformed ATP and phosphocreatine (PCr) pools to delta approximately P during contraction is minor
Richard J. Paul, J. M. Krisanda, R. M. Lynch   +2 more
openaire   +3 more sources

Mechanics of Vascular Smooth Muscle

Comprehensive Physiology, 2016
ABSTRACTVascular smooth muscle (VSM; see Table 1 for a list of abbreviations) is a heterogeneous biomaterial comprised of cells and extracellular matrix. By surrounding tubes of endothelial cells, VSM forms a regulated network, the vasculature, through which oxygenated blood supplies specialized organs, permitting the development of large multicellular
openaire   +3 more sources

Vascular Smooth Muscle

2005
Vascular smooth muscle cells (VSMCs) are a major component of arteries, veins and small blood vessels. Their main function is to maintain vascular tone, via co-ordinated vasoconstriction and vasorelaxation, thereby regulating blood pressure and flow.
Diane Proudfoot, Catherine M. Shanahan
openaire   +2 more sources

Mechanotransduction by Vascular Smooth Muscle

Journal of Vascular Research, 1995
Mechanotransduction by vascular smooth muscle (VSM) is defined as a cellular response (contraction, secretion, growth, division) to transmural pressure or stretch. This review includes an overview of the physical forces VSM cells experience in vivo, consideration of experimental techniques used to study VSM mechanotransduction, and a discussion of the ...
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Leptin and Vascular Smooth Muscle Cells

Current Pharmaceutical Design, 2014
This review concerns the influence of leptin on vascular smooth muscle cells (VSMC). VSMC express different isoforms of the leptin receptor (Ob-R) able to activate a wide range of intracellular signalling pathways, mediating many relevant biological actions.
TROVATI, Mariella, DORONZO, GABRIELLA, BARALE, CRISTINA, Vaccheris C, RUSSO, Isabella, Cavalot F.   +5 more
openaire   +4 more sources