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Transcription Factors and Muscle Differentiation
2010Through their ability to repress irreversible cell cycle arrest, some transcription factors such as cellular oncogenes are considered as potent repressors of myoblast differentiation. Interestingly, their expression and/or activity are regulated by ligand-dependent transcription factors. Indeed, functional interactions between these proteins are deeply
Cabello, Gerard +2 more
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Myocardin and smooth muscle differentiation
Archives of Biochemistry and Biophysics, 2014Myocardin (MYOCD), a co-transcriptional activator of serum response factor (SRF), stimulates the expression of smooth muscle (SM) genes and inhibits the cell cycle. In addition to its roles in the development, MYOCD may be critically involved in the pathogenesis of proliferative vascular diseases.
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Soft Tissue Tumors with Muscle Differentiation
Seminars in Musculoskeletal Radiology, 2010The working group of the World Health Organization (WHO) updated its classification of soft tissue and bone tumors in 2002, and modifications were made primarily to the nomenclature for soft tissue neoplasms. This review presents the imaging features, patient demographics, and clinicopathological findings for benign and malignant skeletal and smooth ...
Charlotte E, Davies +3 more
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M-twist Is an Inhibitor of Muscle Differentiation
Developmental Biology, 1994The twist gene encodes a transcription factor containing a conserved basic helix-loop-helix domain. During development, transcription factors of this type are normally associated with the induction of differentiation. Yet the expression pattern of the murine M-twist suggests an inhibitory role during muscle differentiation.
M, Hebrok, K, Wertz, E M, Füchtbauer
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Ionic Control of Postsynaptic Differentiation in Muscle
The Biological Bulletin, 1989The formation of acetylcholine receptor (AChR) clusters in cultured Xenopus muscle cells can be effected by polycation-coated latex beads. In a manner resembling innervation, the beads induce AChR clustering discretely at the bead-muscle contacts. In this study, we examined the role of intracellular Ca2+ and pH on the development of this postsynaptic ...
Peng, H. Benjamin, Zhu, D.L.
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Skeletal Muscle Differentiation
1992Skeletal muscle is one of the best characterized cell types in multicellular eucaryotic animals and is a striking example of the relationship between structural organization and differentiated function. Skeletal muscle has been the subject of intense cell biological and biochemical investigations that have led to a detailed understanding of the ...
Deborah F. Pinney, Charles P. Emerson
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Muscle Differentiation: Which myogenic factors make muscle?
Current Biology, 1994Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.
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microRNAs in skeletal muscle differentiation and disease
Clinical Science, 2012miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed miRNAs are also essential for muscle function.
Goljanek-Whysall, Katarzyna +2 more
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Mitochondrial mobility in differentiating muscle heterokaryons
Journal of the Neurological Sciences, 1997Ragged-red fibers, a morphological hallmark of many patients with mitochondrial encephalomyopathies who harbor mitochondrial DNA (mtDNA) mutations, usually contain varying ratios of mutated and wild-type mtDNAs. Deficient respiratory function in muscle is almost invariably segmental.
Walker, Ulrich A. +2 more
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Differentiation of slow and fast muscles in chickens
Cell and Tissue Research, 19771. The development of the characteristic histochemical appearance of the slow anterior latissimus dorsi (ALD) and fast posterior latissimus dorsi (PLD) was studied in chickens during embryonic development as well as during regeneration of minced muscle. 2. During embryonic development the activity of the oxidative enzyme succinic dehydrogenase (SDH) is
T, Gordon +3 more
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