Results 71 to 80 of about 5,696,273 (256)

: Role of Cripto in skeletal muscle regeneration

, 2012
International audienceSkeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here,
Iaconis, S., Guardiola, Ombretta, Brunelli, Silvia, Shen, Michael, M., Touvier, Thierry, Lonardo, Enza, Iaconis, Salvatore, Cossu, Giulio, Bouche, A., Liguori, Giovanna L., Liguori, Giovanna,, Lafuste, Peggy, Shen, M., Mourikis, Philippos, Bouché, Ann, Guardiola, O., Minchiotti, Gabriella, Liguori, G., Carmeliet, Peter, Andolfi, G., Tajbakhsh, S., Minchiotti, G., de Bock, Katrien, Andolfi, Gennaro, Brunelli, S., Shen, Michael M., de Bock, K., Mourikis, P., Lonardo, E., Lafuste, P., Liguori, Giovanna, L., Shen, Michael,, Tajbakhsh, Shahragim, Touvier, T., Cossu, G., Carmeliet, P.   +35 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Estrogen Regulates the Satellite Cell Compartment in Females

Cell Reports, 2019
Summary: Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause.
Brittany C. Collins, Robert W. Arpke, Alexie A. Larson, Cory W. Baumann, Ning Xie, Christine A. Cabelka, Nardina L. Nash, Hanna-Kaarina Juppi, Eija K. Laakkonen, Sarianna Sipilä, Vuokko Kovanen, Espen E. Spangenburg, Michael Kyba, Dawn A. Lowe   +13 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Loss of MyoD and Myf5 in Skeletal Muscle Stem Cells Results in Altered Myogenic Programming and Failed Regeneration

Stem Cell Reports, 2018
Summary: MyoD and Myf5 are fundamental regulators of skeletal muscle lineage determination in the embryo, and their expression is induced in satellite cells following muscle injury.
Masakazu Yamamoto, Nicholas P. Legendre, Arpita A. Biswas, Alexander Lawton, Shoko Yamamoto, Shahragim Tajbakhsh, Gabrielle Kardon, David J. Goldhamer   +7 more
doaj   +1 more source

SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity

, 2018
Muscle satellite cells are the primary source of stem cells for postnatal skeletal muscle growth and regeneration. Understanding genetic control of satellite cell formation, maintenance, and acquisition of their stem cell properties is on-going, and we ...
Mademtzoglou, Despoina, Zammit, Peter, Relaix, Frédéric, Sonia Alonso-Martin, Despoina Mademtzoglou, Anne Rochat, Rochat, Anne, Zammit, Peter S., Alonso-Martin, Sonia, Peter S Zammit, Frédéric Relaix, Auradé, Frédéric, Frédéric Auradé   +12 more
core   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Fibroblast growth factor–inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair

JCI Insight
Skeletal muscle regeneration in adults is predominantly driven by satellite cells. Loss of satellite cell pool and function leads to skeletal muscle wasting in many conditions and disease states.
Meiricris Tomaz da Silva, Aniket S. Joshi, Ashok Kumar   +2 more
doaj   +1 more source

Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways [PDF]

, 2014
Maintenance of skeletal muscle is essential for health and survival. There are marked losses of skeletal muscle mass as well as strength and physiological function under conditions of low mechanical load, such as space flight, as well as ground based ...
Brooks, Naomi, Myburgh, Kathryn H, Naomi E. Brooks, Kathryn H. Myburgh   +3 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source