Results 1 to 10 of about 117,556 (163)

PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. [PDF]

PLoS ONE, 2013
FOXO1 is involved in glucocorticoid- and sepsis-induced muscle wasting, in part reflecting regulation of atrogin-1 and MuRF1. Mechanisms influencing FOXO1 expression in muscle wasting are poorly understood.
Estibaliz Castillero, Nima Alamdari, Zaira Aversa, Aniket Gurav, Per-Olof Hasselgren   +4 more
doaj   +6 more sources

Protective association of renin‐angiotensin system inhibitor use with skeletal muscle wasting in diabetic heart failure [PDF]

Journal of Diabetes Investigation
Aims Muscle wasting is common in heart failure (HF) patients, particularly those with diabetes mellitus (DM). Renin‐angiotensin system inhibitors (RASI) may have muscle‐protective effects, but their association with muscle wasting in diabetic HF patients
Hidemichi Kouzu, Toshiyuki Yano, Satoshi Katano, Wataru Kawaharata, Ryo Numazawa, Ryohei Nagaoka, Hiroki Aida, Katsuhiko Ohori, Takefumi Fujito, Nobutaka Nagano, Masato Furuhashi   +10 more
doaj   +2 more sources

Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis [PDF]

Redox Biology
Recent studies highlight the role of skeletal muscle wasting in the sepsis-associated long-term mortality. Despite clinical recommendations for increased protein intake to counteract muscle wasting, the outcomes have been suboptimal, suggesting that ...
Gang Wang, Ming Chen, Yuheng Zhang, Dacheng Wang, Tao Gao, Jianfeng Duan, Huimin Lu, Minhua Cheng, Yun Xu, Xiaoyao Li, Yan Wang, Ke Cao, Wenkui Yu   +12 more
doaj   +2 more sources

Sepsis-associated skeletal muscle wasting is ameliorated by pharmacological inhibition of the STAT3 signaling pathway in mice [PDF]

Scientific Reports
Patients with sepsis frequently experience skeletal muscle atrophy and weakness, which adversely affect survival and hinder functional recovery. Currently, no approved treatments are available for sepsis-associated muscle wasting.
Yuko Ono, Masafumi Saito, Ikumi Yoshihara, Yutaka Kondo, Kazuho Sakamoto, Jun Sugiyama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani   +8 more
doaj   +2 more sources

Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1 [PDF]

Nature Communications
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, their use is frequently associated with immune-related adverse events (irAEs).
Se-Young Park, Kyuwon Son, Jiwoo Kim, Kyeongah Kim, Sungmin Joo, Bomi Kim, Myunggyo Lee, Wankyu Kim, Won-Jung Jung, Byung Kwan Choi, Nakyung Jeon, Won-Yoon Chung, Yinling Hu, Haeseung Lee, Na-Young Song   +14 more
doaj   +2 more sources

Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis

Cells, 2021
We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI).
Laura Mañas-García, Charlotte Denhard, Javier Mateu, Xavier Duran, Joaquim Gea, Esther Barreiro   +5 more
doaj   +1 more source

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Biomedicines, 2022
As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly ...
Xuejie Wang, Ana Balaña-Corberó, Juana Martínez-Llorens, Liyun Qin, Yingchen Xia, Jianhua Zha, José María Maiques, Esther Barreiro   +7 more
doaj   +1 more source

Systemic Profiles of microRNAs, Redox Balance, and Inflammation in Lung Cancer Patients: Influence of COPD

Biomedicines, 2021
Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients.
Liyun Qin, Maria Guitart, Víctor Curull, Albert Sánchez-Font, Xavier Duran, Jun Tang, Mireia Admetlló, Esther Barreiro   +7 more
doaj   +1 more source

Iron Replacement and Redox Balance in Non-Anemic and Mildly Anemic Iron Deficiency COPD Patients: Insights from a Clinical Trial

Biomedicines, 2021
In COPD patients, non-anemic iron deficiency (NAID) is a common systemic manifestation. We hypothesized that in COPD patients with NAID, iron therapy may improve systemic oxidative stress.
Maria Pérez-Peiró, Clara Martín-Ontiyuelo, Anna Rodó-Pi, Lucilla Piccari, Mireia Admetlló, Xavier Durán, Diego A. Rodríguez-Chiaradía, Esther Barreiro   +7 more
doaj   +1 more source

Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia

Molecules, 2021
Muscle wasting and cachexia are prominent comorbidities in cancer. Treatment with polyphenolic compounds may partly revert muscle wasting. We hypothesized that treatment with curcumin or resveratrol in cancer cachectic mice may improve muscle phenotype ...
Antonio Penedo-Vázquez, Xavier Duran, Javier Mateu, Adrián López-Postigo, Esther Barreiro   +4 more
doaj   +1 more source