Results 11 to 20 of about 115,632 (206)
PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. [PDF]
PLoS ONE, 2013 FOXO1 is involved in glucocorticoid- and sepsis-induced muscle wasting, in part reflecting regulation of atrogin-1 and MuRF1. Mechanisms influencing FOXO1 expression in muscle wasting are poorly understood.
Estibaliz Castillero +4 more
doaj +6 more sources
Protective association of renin‐angiotensin system inhibitor use with skeletal muscle wasting in diabetic heart failure [PDF]
Journal of Diabetes InvestigationAims Muscle wasting is common in heart failure (HF) patients, particularly those with diabetes mellitus (DM). Renin‐angiotensin system inhibitors (RASI) may have muscle‐protective effects, but their association with muscle wasting in diabetic HF patients
Hidemichi Kouzu +10 more
doaj +2 more sources
MicroRNAs in muscle wasting [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2018 Skeletal muscle makes up approximately 40% of the total body mass; it is essential in providing structural support, to regulate motion and as an energy store, thereby playing a major role in the overall metabolism. Skeletal muscle retains a high plasticity in order to respond to various stimuli, which subsequently lead to changes in gene transcription ...
Tsuyoshi Suzuki, Jochen Springer
doaj +5 more sources
Transcriptomic insights into aerobic exercise-mediated attenuation of high-fat diet–induced muscle wasting [PDF]
Frontiers in PhysiologyChronic consumption of high-fat diets (HFDs) induces obesity and metabolic dysfunction and is accompanied by progressive skeletal muscle wasting. Although aerobic exercise is generally considered less effective for maintaining muscle mass, accumulating ...
Weihao Hong +6 more
doaj +2 more sources
Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis [PDF]
Redox BiologyRecent studies highlight the role of skeletal muscle wasting in the sepsis-associated long-term mortality. Despite clinical recommendations for increased protein intake to counteract muscle wasting, the outcomes have been suboptimal, suggesting that ...
Gang Wang +12 more
doaj +2 more sources
Sepsis-associated skeletal muscle wasting is ameliorated by pharmacological inhibition of the STAT3 signaling pathway in mice [PDF]
Scientific ReportsPatients with sepsis frequently experience skeletal muscle atrophy and weakness, which adversely affect survival and hinder functional recovery. Currently, no approved treatments are available for sepsis-associated muscle wasting.
Yuko Ono +8 more
doaj +2 more sources
Chemotherapy-induced muscle wasting: an update
European Journal of Translational Myology, 2018 The majority of cancers are associated to cachexia, a severe form of weight loss mostly accounted for by skeletal muscle wasting. Cancer patients are often treated with chemotherapy, whose side effects are at times neglected or underestimated ...
Dario Coletti
doaj +4 more sources
Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1 [PDF]
Nature CommunicationsImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, their use is frequently associated with immune-related adverse events (irAEs).
Se-Young Park +14 more
doaj +2 more sources
Muscle-tendon cross talk during muscle wasting [PDF]
American Journal of Physiology-Cell Physiology, 2021 In organisms from flies to mammals, the initial formation of a functional tendon is completely dependent on chemical signals from muscles (myokines). However, how myokines affect the maturation, maintenance, and regeneration of tendons as a function of age is completely unstudied.
Alec M. Avey, Keith Baar
openaire +4 more sources
Biomedicines, 2022 As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly ...
Xuejie Wang +7 more
doaj +1 more source